Antioxidant Effects of Selenium in Adult Critically Ill Patients A Systematic Review and Meta-analysis of Randomized Controlled Trials

被引：0

作者：

Hasani, Motahareh ^{[1
,2
]}

Agh, Fahimeh ^{[3
]}

Irandoost, Pardis ^{[4
]}

Farsi, Farnaz ^{[5
]}

Khodabakhshi, Adeleh ^{[4
]}

Heshmati, Javad ^{[6
]}

Pizarro, Ana Beatriz ^{[7
]}

Aghamohamadi, Vahideh ^{[8
]}

Khazdouz, Maryam ^{[4
,9
,10
]}

机构：

[1] Golestan Univ Med Sci, Hlth Management & Social Dev Res Ctr, Gorgan, Iran

[2] Golestan Univ Med Sci, Sch Hlth, Dept Nutr Sci, Gorgan, Iran

[3] Saveh Univ Med Sci, Saveh, Iran

[4] Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Tehran, Iran

[5] Iran Univ Med Sci, Minimally Invas Surg Res Ctr, Tehran, Iran

[6] Kermanshah Univ Med Sci, Songhor Healthcare Ctr, Kermanshah, Iran

[7] Fdn Valle Lili, Clin Res Ctr, Cali, Colombia

[8] Khalkhal Univ Med Sci, Dept Nutr, Ardebil, Iran

[9] Univ Tehran Med Sci, Growth & Dev Res Ctr, Tehran, Iran

[10] Iran Univ Med Sci, Nutr Dept, Tehran, Iran

来源：

TOPICS IN CLINICAL NUTRITION | 2023年 / 38卷 / 03期

关键词：

antioxidant; critical illness; intensive care unit; selenium; INFLAMMATORY RESPONSE SYNDROME; KAPPA-B ACTIVATION; OXIDATIVE STRESS; SEPSIS; SUPPLEMENTATION; MACROPHAGES; EXPRESSION; THERAPY; SYNTHASE;

D O I：

10.1097/TIN.0000000000000326

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Oxidative stress is the fundamental etiology of inflammation and organ failure, and unfavorable consequences characterize critical illness. We searched systematically up to September 2021 to find related randomized controlled trials (RCTs) that investigated the effects of selenium in antioxidant markers of the critically ill. A total of 10 RCTs were included. The results indicated that selenium administration has no significant effects on glutathione peroxidase activity (standardized mean difference [SMD]: 1.67, 95% confidence interval [CI]: -0.01 to 3.35) and C-reactive protein levels (SMD: -0.21 mg/L, 95% CI: -0.45 to 0.03). Further trials are needed to prove the potential effects of selenium administration on antioxidant and inflammation markers.

引用

页码：224 / 238

页数：15

共 42 条

[1] The Effect of Selenium Therapy on Mortality in Patients With Sepsis Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials [J].