Timing and implications for immune response to vaccine in SARS-CoV-2 breakthrough infections

被引：3

作者：

Arsuffi, Stefania ^{[1
,2
]}

Sansone, Emanuele ^{[2
,3
]}

Foca, Emanuele ^{[1
,2
]}

Storti, Samuele ^{[1
,2
]}

Diaferia, Teresa ^{[2
,3
]}

Bonfanti, Carlo ^{[2
,4
]}

Terlenghi, Luigina ^{[2
,4
]}

Caruso, Arnaldo ^{[2
,4
]}

Sala, Emma ^{[2
,3
]}

Castelli, Francesco ^{[1
,2
]}

De Palma, Giuseppe ^{[2
,3
]}

Quiros-Roldan, Eugenia ^{[1
,2
]}

机构：

[1] Univ Brescia, Unit Infect & Trop Dis, Brescia, Italy

[2] ASST Spedali Civili Hosp, Brescia, Italy

[3] Univ Brescia, Dept Occupat Hlth & Ind Hyg, Brescia, Italy

[4] Univ Brescia, Microbiol Dept, Brescia, Italy

来源：

ISCIENCE | 2023年 / 26卷 / 01期

关键词：

HEALTH-CARE WORKERS; COVID-19; ANTIBODY;

D O I：

10.1016/j.isci.2023.106716

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

COVID-19 vaccines elicit a strong anti-S antibodies response. We aim to describe antibody titers in peri-vaccination SARS-CoV-2 infections. This is a retrospective longitudinal single-cohort study. Serological tests were performed at the time of the first SARS-CoV-2 vaccine dose (T0) and 60 (T1), 120 (T2), and 240 (T3) days after. The study included 4,682 subjects. Group A had the infection without an anti-S Ig response. Group B and C seroconverted for anti-N Ig between T0 and T1 and be-tween T1 and T2, respectively. Group D was persistently anti-N Ig negative. Group B showed an initial sub-optimal response, reaching the highest titer at T3. Those who received the second dose 120 days after the infection had higher titers compared to those who received it 21 days after the first dose. The immune response depends on the number and the timing of vaccine doses, highlighting the need for a more personalized approach to vaccination.

引用

页数：12

共 30 条

[1] Postvaccination COVID-19 among Healthcare Workers, Israel [J].

Amit, Sharon ;

Beni, Sharon Alexsandra ;

Biber, Asaf ;

Grinberg, Amir ;

Leshem, Eyal ;

Regev-Yochay, Gili .

EMERGING INFECTIOUS DISEASES, 2021, 27 (04) :1220-1222

[2] Association Between Vaccination With BNT162b2 and Incidence of Symptomatic and Asymptomatic SARS-CoV-2 Infections Among Health Care Workers [J].

Angel, Yoel ;

Spitzer, Avishay ;

Henig, Oryan ;

Saiag, Esther ;

Sprecher, Eli ;

Padova, Hagit ;

Ben-Ami, Ronen .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2021, 325 (24) :2457-2465

[3] Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine [J].

Baden, Lindsey R. ;

El Sahly, Hana M. ;

Essink, Brandon ;

Kotloff, Karen ;

Frey, Sharon ;

Novak, Rick ;

Diemert, David ;

Spector, Stephen A. ;

Rouphael, Nadine ;

Creech, C. Buddy ;

McGettigan, John ;

Khetan, Shishir ;

Segall, Nathan ;

Solis, Joel ;

Brosz, Adam ;

Fierro, Carlos ;

Schwartz, Howard ;

Neuzil, Kathleen ;

Corey, Larry ;

Gilbert, Peter ;

Janes, Holly ;

Follmann, Dean ;

Marovich, Mary ;

Mascola, John ;

Polakowski, Laura ;

Ledgerwood, Julie ;

Graham, Barney S. ;

Bennett, Hamilton ;

Pajon, Rolando ;

Knightly, Conor ;

Leav, Brett ;

Deng, Weiping ;

Zhou, Honghong ;

Han, Shu ;

Ivarsson, Melanie ;

Miller, Jacqueline ;

Zaks, Tal .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (05) :403-416

[4] Immunogenicity and risk of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection after Coronavirus Disease 2019 (COVID-19) vaccination in patients with cancer: a systematic review and meta-analysis [J].

Becerril-Gaitan, Andrea ;

Vaca-Cartagena, Bryan F. ;

Ferrigno, Ana S. ;

Mesa-Chavez, Fernanda ;

Barrientos-Gutierrez, Tonatiuh ;

Tagliamento, Marco ;

Lambertini, Matteo ;

Villarreal-Garza, Cynthia .

EUROPEAN JOURNAL OF CANCER, 2022, 160 :243-260

[5] Covid-19 Breakthrough Infections in Vaccinated Health Care Workers [J].

Bergwerk, Moriah ;

Gonen, Tal ;

Lustig, Yaniv ;

Amit, Sharon ;

Lipsitch, Marc ;

Cohen, Carmit ;

Mandelboim, Michal ;

Gal Levin, Einav ;

Rubin, Carmit ;

Indenbaum, Victoria ;

Tal, Ilana ;

Zavitan, Malka ;

Zuckerman, Neta ;

Bar-Chaim, Adina ;

Kreiss, Yitshak ;

Regev-Yochay, Gili .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (16) :1474-1484

[6] Serological Response to SARS-CoV-2 in Health Care Workers Employed in a Large Tertiary Hospital in Lombardy, Northern Italy [J].

Comelli, Agnese ;

Foca, Emanuele ;

Sansone, Emanuele ;

Tomasi, Cesare ;

Albini, Elisa ;

Quiros-Roldan, Eugenia ;

Tomasoni, Lina Rachele ;

Sala, Emma ;

Bonfanti, Carlo ;

Caccuri, Francesca ;

Caruso, Arnaldo ;

De Palma, Giuseppe ;

Castelli, Francesco .

MICROORGANISMS, 2021, 9 (03) :1-13

[7] Evidence for antibody as a protective correlate for COVID-19 vaccines [J].

Earle, Kristen A. ;

Ambrosino, Donna M. ;

Fiore-Gartland, Andrew ;

Goldblatt, David ;

Gilbert, Peter B. ;

Siber, George R. ;

Dull, Peter ;

Plotkin, Stanley A. .

VACCINE, 2021, 39 (32) :4423-4428

[8] Neutralizing Antibodies Against SARS-CoV-2 Variants After Infection and Vaccination [J].

Edara, Venkata Viswanadh ;

Hudson, William H. ;

Xie, Xuping ;

Ahmed, Rafi ;

Suthar, Mehul S. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2021, 325 (18) :1896-1898

[9] A Monovalent Chimpanzee Adenovirus Ebola Vaccine Boosted with MVA [J].

Ewer, K. ;

Rampling, T. ;

Venkatraman, N. ;

Bowyer, G. ;

Wright, D. ;

Lambe, T. ;

Imoukhuede, E. B. ;

Payne, R. ;

Fehling, S. K. ;

Strecker, T. ;

Biedenkopf, N. ;

Kraehling, V. ;

Tully, C. M. ;

Edwards, N. J. ;

Bentley, E. M. ;

Samuel, D. ;

Labbe, G. ;

Jin, J. ;

Gibani, M. ;

Minhinnick, A. ;

Wilkie, M. ;

Poulton, I. ;

Lella, N. ;

Roberts, R. ;

Hartnell, F. ;

Bliss, C. ;

Sierra-Davidson, K. ;

Powlson, J. ;

Berrie, E. ;

Tedder, R. ;

Roman, F. ;

De Ryck, I. ;

Nicosia, A. ;

Sullivan, N. J. ;

Stanley, D. A. ;

Mbaya, O. T. ;

Ledgerwood, J. E. ;

Schwartz, R. M. ;

Siani, L. ;

Colloca, S. ;

Folgori, A. ;

Di Marco, S. ;

Cortese, R. ;

Wright, E. ;

Becker, S. ;

Graham, B. S. ;

Koup, R. A. ;

Levine, M. M. ;

Volkmann, A. ;

Chaplin, P. .

NEW ENGLAND JOURNAL OF MEDICINE, 2016, 374 (17) :1635-1646

[10] Modeling the effect of boost timing in murine irradiated sporozoite prime-boost vaccines [J].

Fernandez-Arias, Cristina ;

Arias, Clemente F. ;

Zhang, Min ;

Herrero, Miguel A. ;

Acosta, Francisco J. ;

Tsuji, Moriya .

PLOS ONE, 2018, 13 (01)

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