Selenium status in term neonates, according to birth weight and gestational age, in relation to maternal hypertensive pathology

被引:1
作者
Bizerea-Moga, Teofana Otilia [1 ,2 ]
Pitulice, Laura [3 ,4 ]
Bizerea-Spiridon, Otilia [3 ,4 ]
Angelescu, Claudiu [5 ]
Marginean, Otilia [1 ,2 ]
Moga, Tudor Voicu [6 ,7 ]
机构
[1] Victor Babes Univ Med & Pharm Timisoara, Ctr Res Growth & Dev Disorders Children, Dept Pediat 11, Pediat Discipline 1, Timisoara, Romania
[2] Louis Turcanu Childrens Clin & Emergency Hosp, Pediat Clin 1, Timisoara, Romania
[3] West Univ Timisoara, Dept Biol Chem, Timisoara, Romania
[4] Lab Adv Res Environm Protect, Timisoara, Romania
[5] Pius Brinzeu Cty Emergency Clin Hosp, Clin Obstet Gynecol & Neonatol, Timisoara, Romania
[6] Victor Babes Univ Med & Pharm, Adv Reg Res Ctr Gastroenterol & Hepatol, Dept Internal Med 7, Gastroenterol Discipline, Timisoara, Romania
[7] Pius Brinzeu Cty Emergency Clin Hosp, Gastroenterol & Hepatol Clin, Timisoara, Romania
关键词
pregnancy-induced hypertension; oxidative stress; selenium; neonate; gestational age; birthweight; ENTERAL YEAST-SELENIUM; CORD BLOOD; GROWTH RESTRICTION; OXIDATIVE STRESS; FULL-TERM; PRETERM; SUPPLEMENTATION; PLACENTA; PREGNANCY; SELENOPROTEINS;
D O I
10.3389/fped.2023.1157689
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
BackgroundPregnancy represents a state of increased oxidative stress and antioxidants, in which selenium (Se) plays a pivotal role, contribute to maintain the oxidative balance. If antioxidant defenses are depleted, placental function is disrupted, resulting in pregnancy complications, including pregnancy-induced hypertension (PIH). Little is known about fetal selenium status in concomitant relation to maternal PIH, gestational age (GA) and birthweight (BW). MethodsWe examined over a 3-year period the serum (SeS) and urine selenium (SeU) status in term neonates from normotensive (nonPIH) and hypertensive (PIH) mothers as clinical markers of oxidative stress. In this retrospective observational study, 72 neonates with maternal PIH were matched for GA and BW to 72 neonates of normotensive mothers. Four groups were obtained, based on maternal PIH and BW relative to GA (appropriate-for-gestational-age-AGA, small-for-gestational-age-SGA): nonPIH-AGA (control group), nonPIH-SGA, PIH-AGA, and PIH-SGA. ResultsThe results showed significant differences (p < 0.001) in selenium levels among the study groups: SeS - 44.85 +/- 7.56 mu g/L in nonPIH-AGA, 39.62 +/- 11.42 mu g/L in nonPIH-SGA, 40.01 +/- 10.07 mu g/L in PIH-AGA, and 25.39 +/- 8.99 mu g/L in PIH-SGA; SeU - 27.98 +/- 7.99 mu g/L in nonPIH-AGA, 22.85 +/- 9.48 mu g/L in nonPIH-SGA, 23.44 +/- 6.73 mu g/L in PIH-AGA, and 13.05 +/- 5.86 mu g/L in PIH-SGA. Selenium depletion was more common in neonates born from hypertensive mothers and those born small for gestational age. Though moderate in intensity, selenium levels were positively correlated with BW (0.319 for SeS, 0.397 for SeU) and negatively correlated with maternal systolic blood pressure (-0.313 for SeS, -0.324 for SeU). The main independent effects on SeS and SeU of each maternal blood pressure and birth weight turned out statistically significant. In interaction, a more pronounced effect was reached in PIH-SGA neonates. ConclusionSelenium status seemed to reflect the negative impact that PIH exerts in neonates during intrauterine development. Clinical markers of selenium status could thus be of great value for tracking responses of individuals to selenium supplementation as part of health improvement and harm mitigation approaches.
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页数:11
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