Simultaneous determination of four antibiotics in human plasma by high-performance LC-MS/MS: application to therapeutic drug monitoring

被引：2

作者：

Liu, Hongchuan ^{[1
]}

Yu, Xiaojia ^{[1
]}

Hu, Ting ^{[1
]}

Han, Feifei ^{[1
]}

An, Zhuoling ^{[1
]}

Zhao, Rui ^{[1
]}

机构：

[1] Capital Med Univ, Beijing Chao Yang Hosp, Dept Pharm, Beijing 100020, Peoples R China

来源：

BIOANALYSIS | 2023年 / 15卷 / 05期

关键词：

antibiotics; HPLC-MS; MS; human plasma analysis; method validation; therapeutic drug monitoring; INFECTIOUS-DISEASES SOCIETY; MASS-SPECTROMETRY ASSAY; 2016; UPDATE; VORICONAZOLE; MANAGEMENT; GUIDELINES;

D O I：

10.4155/bio-2023-0020

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Background: Aimed to simultaneously measure linezolid, voriconazole, cefoperazone and fluconazole in human plasma suitable for therapeutic drug monitoring applications, a robust, rapid and easy-to-use HPLC-MS/MS approach was developed and validated. Materials & methods: Protein precipitation was used to prepare analytes from 100 mu l plasma. HPLC was employed for analyte separation, and quantification was conducted via multiple reaction monitoring in positive ion mode. The methodology was fully validated. Results & conclusion: All four antibiotics were found to be stable under the tested conditions, and accuracy values ranged from 90.96 to 113.25% and CV values were <14.0%. This HPLC-MS/MS method can be used for routine clinical therapeutic drug monitoring of linezolid, voriconazole, cefoperazone and fluconazole simultaneously.

引用

页码：269 / 282

页数：14

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