Safe Use of Cenobamate in Super Refractory Status Epilepticus: A Case Series

被引：4

作者：

Carlson, Julia M. ^{[1
]}

Molyneaux, Bradley J. ^{[1
]}

Lee, Jong Woo ^{[1
,2
]}

机构：

[1] Brigham & Womens Hosp, Dept Neurol, Boston, MA USA

[2] Brigham & Womens Hosp, Neurosci Ctr, 60 Fenwood Rd,1st Floor,Hale Bldg Transformat Med, Boston, MA 02115 USA

来源：

NEUROHOSPITALIST | 2023年 / 13卷 / 02期

基金：

美国国家卫生研究院;

关键词：

cenobamate; super refractory status epilepticus; status epilepticus; ADJUNCTIVE CENOBAMATE;

D O I：

10.1177/19418744221147083

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cenobamate is an effective new adjunctive antiseizure medication (ASM) for treatment resistant focal epilepsy. It has broad spectrum anticonvulsant activity and may be a useful medication for super refractory status epilepticus (SRSE), but has not yet been studied in generalized seizures or an inpatient setting. Here we describe 2 SRSE cases where cenobamate was added safely to other treatments. It was uptitrated slowly to reduce the risk of hypersensitivity reactions which have been observed previously with rapid increasing dosages. Both patients achieved seizure control and liberation from intensive care. They have remained seizure free with continued treatment and have not experienced any side effects attributable to cenobamate. Cenobamate warrants further examination in patients with refractory status epilepticus.

引用

页码：169 / 172

页数：4

共 7 条

[1]

[Anonymous], 2018, NEW ONSET REFRACTORY

[2] Randomized phase 2 study of adjunctive cenobamate in patients with uncontrolled focal seizures [J].

Chung, Steve S. ;

French, Jacqueline A. ;

Kowalski, Jacek ;

Krauss, Gregory L. ;

Lee, Sang Kun ;

Maciejowski, Maciej ;

Rosenfeld, William E. ;

Sperling, Michael R. ;

Mizne, Sarah ;

Kamin, Marc .

NEUROLOGY, 2020, 94 (22) :E2311-E2322

[3] An Ex Vivo Evaluation of Cenobamate Administered via Enteral Tubes [J].

Ferrari, Louis ;

Nisman, Arkady ;

Pegan, Augustin ;

Ursino, Jordan .

DRUGS IN R&D, 2020, 20 (02) :125-133

[4] Safety and efficacy of adjunctive cenobamate (YKP3089) in patients with uncontrolled focal seizures: a multicentre, double-blind, randomised, placebo-controlled, dose-response trial [J].

Krauss, Gregory L. ;

Klein, Pavel ;

Brandt, Christian ;

Lee, Sang Kun ;

Milanov, Ivan ;

Milovanovic, Maja ;

Steinhoff, Bernhard J. ;

Kamin, Marc .

LANCET NEUROLOGY, 2020, 19 (01) :38-48

[5] Pharmacology of Cenobamate: Mechanism of Action, Pharmacokinetics, Drug-Drug Interactions and Tolerability [J].

Roberti, Roberta ;

De Caro, Carmen ;

Iannone, Luigi Francesco ;

Zaccara, Gaetano ;

Lattanzi, Simona ;

Russo, Emilio .

CNS DRUGS, 2021, 35 (06) :609-618

[6] Cenobamate for treatment-resistant focal seizures: current evidence and place in therapy [J].

Singh, Alok .

JOURNAL OF CENTRAL NERVOUS SYSTEM DISEASE, 2022, 14

[7] Cenobamate (YKP3089) as adjunctive treatment for uncontrolled focal seizures in a large, phase 3, multicenter, open-label safety study [J].

Sperling, Michael R. ;

Klein, Pavel ;

Aboumatar, Sami ;

Gelfand, Michael ;

Halford, Jonathan J. ;

Krauss, Gregory L. ;

Rosenfeld, William E. ;

Vossler, David G. ;

Wechsler, Robert ;

Borchert, Leona ;

Kamin, Marc .

EPILEPSIA, 2020, 61 (06) :1099-1108

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