Effect of YC-1102 on the Improvement of Obesity in High-Fat Diet-Induced Obese Mice

被引:1
作者
Yu, Hwa-Young [1 ]
Kim, Kyoung Kon [2 ]
Baek, Sin Hwa [3 ,4 ]
Park, Cho, I [3 ,4 ]
Jeon, Hye Jin [3 ,4 ]
Song, Ae Ri [3 ,4 ]
Park, Hyun-Je [3 ,4 ]
Park, Il Bum [3 ]
Kang, Jong Soo [5 ]
Kim, Jung Min [2 ]
Kim, Tae Woo [2 ]
Jang, Sun Min [2 ]
Cha, Joo Young [3 ,4 ,6 ]
Kim, Junghyun [1 ,7 ]
机构
[1] Jeonbuk Natl Univ, Sch Dent, Dept Oral Pathol, Jeonju 54907, South Korea
[2] Newgen Healthcare Co Ltd, 56 Soyanggang Ro, Chunchon 24232, South Korea
[3] Yuhan Care Co Ltd, Yuhan Care R&D Ctr, Yongin 17084, South Korea
[4] Yuhan Care Co Ltd, Yuhan Nat Prod R&D Ctr, Andong Si 36618, South Korea
[5] Yuhan Care Co Ltd, Seoul 07335, South Korea
[6] Seoul Natl Univ, Grad Sch Convergence Sci & Technol, Dept Mol Med & Biopharmaceut Sci, Seoul 08826, South Korea
[7] Jeonbuk Natl Univ Hosp, Nonclin Evaluat Ctr, Biomed Res Inst, Jeonju 57907, South Korea
关键词
obesity; adipogenesis; high-fat diet; Rosa multiflora; YC-1102; ADIPOSE-TISSUE; CONDENSED TANNINS; ADIPONECTIN; LEPTIN; ROOTS; WHITE; BROWN; ACID;
D O I
10.3390/cimb46020093
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Obesity is one of the major risk factors for metabolic diseases worldwide. This study examined the effects of YC-1102, an extract derived from the roots of Rosa multiflora, on 3T3-L1 preadipocytes and high-fat diet (HFD)-induced obese mice. In vivo experiments involved the oral administration of YC-1102 (100, 150, and 200 mg/kg body weight) daily to mice for eight weeks. YC-1102 was found to downregulate the expressions of PPAR gamma and C/EBP alpha during adipogenesis, inhibiting adipocyte differentiation and upregulating the expression of PGC-1 alpha for energy metabolism to enhance mitochondrial biogenesis and fatty acid oxidation. It has been shown that daily administration of YC-1102 to mice receiving a HFD prevented an increase in body weight and the accumulation of body fat. YC-1102 administration also reduced TG, TC, and LDL cholesterol levels, as well as glucose and leptin levels, and increased adiponectin levels, thus effectively inhibiting the metabolism of lipids. YC-1102-treated mice showed significant reductions in the mRNA expression of PPAR gamma and C/EBP alpha. The levels of PGC-1 alpha involved in energy metabolism increased significantly in the YC-1102-treated mice when compared to the HFD-treated mice. According to the findings of this study, YC-1102 has a dual mechanism that reduces transcription factors that promote the differentiation of adipocytes and increases transcription factors that promote energy consumption.
引用
收藏
页码:1437 / 1450
页数:14
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