Great enhancement of sensitivity for SARS-CoV-2 detection by integrated graphene FET biosensor using ζ potential modulator

被引：1

作者：

Yamamoto, Kaori ^{[1
]}

Sato, Natsuki ^{[1
]}

Sakano, Kiyoji ^{[1
]}

Yano, Mamiko ^{[1
]}

Ohnishi, Eriko ^{[1
]}

Ono, Takao ^{[1
]}

Kanai, Yasushi ^{[1
]}

Ushiba, Shota ^{[2
]}

Miyakawa, Naruto ^{[2
]}

Tani, Shinsuke ^{[2
]}

Kimura, Masahiko ^{[2
]}

Watanabe, Yohei ^{[3
]}

Inoue, Koichi ^{[1
]}

Tanaka, Hidekazu ^{[1
]}

Matsumoto, Kazuhiko ^{[1
]}

机构：

[1] Osaka Univ, Ibaraki, Osaka 5670047, Japan

[2] Murata Mfg Co Ltd, 1-10-1 Higashikotari, Nagaokakyo, Kyoto 6178555, Japan

[3] Kyoto Prefecture Univ Med, Kajii Cho,Kamigyo Ku, Kyoto, Kyoto 6028566, Japan

来源：

JAPANESE JOURNAL OF APPLIED PHYSICS | 2024年 / 63卷 / 03期

关键词：

graphene; biosensor; SARS-CoV-2; sigma potential; influenza virus; FET; antibody; FIELD-EFFECT TRANSISTORS;

D O I：

10.35848/1347-4065/ad1e99

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

By modulating a zeta potential of graphene FET (G-EFT), the sensitivity of G-FET could be enhanced than that without modulation. Therefore, 1 x 107 FFU ml-1 SARS-CoV-2 was detected using G-FET modified with the zeta potential modulator which is the cation polymer with the positive charge. This method is based on the relationship between the surface charge and the sensitivity, in which the highest sensitivity is obtained when the zeta potential is 0 and/or the surface charge is almost 0. In this study, the microfluidic channel was installed on G-FET to get the precise result because it could wash away the free-floating virus and the physical adsorbed virus. 32 G-FETs including the reference FETs were integrated on the silicon substrate and the precise results were obtained by subtracting the noise terms.

引用

页数：6

共 37 条

[11] IgG Antibody 3D Structures and Dynamics [J].