Gut microbiota of Suncus murinus, a naturally obesity-resistant animal, improves the ecological diversity of the gut microbiota in high-fat-diet-induced obese mice

被引:4
作者
Zhang, Mingshou [1 ]
Yang, Ting [1 ]
Li, Rujia [1 ]
Ren, Ke [2 ]
Li, Jun [3 ]
He, Maozhang [4 ]
Chen, Juefei [1 ]
Yi, Shuang-Qin [1 ]
机构
[1] Tokyo Metropolitan Univ, Grad Sch Human Hlth Sci, Dept Frontier Hlth Sci, Tokyo, Japan
[2] Qujing Normal Univ, Fac Phys Educ, Qujing, Yun Nan, Peoples R China
[3] Shanghai Jiao Tong Univ, Ren Ji Hosp, Shanghai Canc Inst, Sch Med,State Key Lab Oncogenes & Related Genes, Shanghai, Peoples R China
[4] Anhui Med Univ, Sch Basic Med Sci, Dept Microbiol, Hefei, Peoples R China
来源
PLOS ONE | 2023年 / 18卷 / 11期
关键词
HOUSE MUSK SHREW; SURGICAL ANATOMY; INSULIN-RESISTANCE; INNERVATION; TRANSPLANTATION; PANCREAS;
D O I
10.1371/journal.pone.0293213
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background The global population of obese individuals is increasing, affecting human health. High-fat diets are a leading cause of this epidemic, and animal models, such as mice, are often used in related research. Obese individuals have a different gut microbiota composition from non-obese ones, characterized by a sizeable population of certain bacteria associated with fat storage. The gut microbiome plays a significant role in regulating human physiological and metabolic functions. Links between obesity, high-fat diets and gut microbiota have become hot topics of discussion. Recently, research on the modulation of the gut microbiota has focused on fecal microbiota transplantation (FMT), which has been recognized as an effective method of studying the function of gut microbiota. Objectives The purpose of this study was to investigate how the gut microbiota of Suncus murinus, a naturally obesity-resistant animal, through FMT, affected the ecology of the gut microbiota of high-fat diet induced obese mice. Methods In this study, Suncus murinus was used as a donor for FMT. High-fat diet induced C57BL/6NCrSIc mice were used as recipients, the body weight changes were measured and changes in their gut flora were analyzed using a 16S rRNA gene analysis. Results The study found that, after the FMT procedure, the FMT group tended to have a lower body weight than the control group. At the phylum level, the most predominant phyla in all groups were Firmicutes and Proteobacteria, while Deferribacteres was not detected in the FMT or antibiotic administration groups, and Bacteroidetes was not present in the antibiotic administration group. At the genus level, the FMT group had significantly lower OTU richness than the control group but greater diversity than the control group. Conclusions These results indicate that FMT from Suncus murinus can help reorganize and improve the gut microbiota of mice in a balanced and diverse ecosystem.
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页数:17
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