STUDY OF COBALAMIN ADDUCTS WITH CYSTEINE AND ITS OXIDIZED SULFENIC, SULFINIC AND SULFONIC DERIVATIVES

被引：0

作者：

Gaina-Gardiuta, Artiom ^{[1
]}

Lupan, Alexandru ^{[1
]}

Branzanic, Adrian M. V. ^{[2
]}

Silaghi-Dumitrescu, Radu ^{[1
]}

机构：

[1] Babes Bolyai Univ, Dept Chem, Str Arany Janos 11, RO-400028 Cluj Napoca, Romania

[2] Babes Bolyai Univ, Raluca Ripan Inst Res Chem, Fantanele 30, Cluj Napoca 400294, Romania

来源：

REVUE ROUMAINE DE CHIMIE | 2023年 / 68卷 / 3-4期

关键词：

HYDROGEN-SULFIDE; VITAMIN-B-12; REDOX; COMPLEXES; CHEMISTRY; COBINAMIDE; REACTIVITY; MECHANISM; CATALYSIS; KINETICS;

D O I：

10.33224/rrch.2023.68.3-4.04

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this paper, the reactivity of cobalamin towards S-oxidized cysteine derivatives (sulfenic, sulfinic, sulfonic and S-sulfate) is analyzed and compared to the reactivity towards related nitrogen, oxygen and sulfur-based ligands, focusing on the concept of linkage isomerism. UV-Vis spectra complemented by DFT and TD-DFT calculations show that cysteine and its oxidized derivatives do yield adducts, with a preference for binding to the cobalt through the sulfur.

引用

页码：143 / 151

页数：9

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