Characterization of Glutathione Dithiophosphates as Long-Acting H2S Donors
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作者:
Ishkaeva, Rezeda A. A.
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Kazan Volga Reg Fed Univ, Inst Fundamental Med & Biol, 18 Kremlyovskaya St, Kazan 420008, Russia
Kazan Volga Reg Fed Univ, Sci & Educ Ctr Pharmaceut, 18 Kremlyovskaya St, Kazan 420008, RussiaKazan Volga Reg Fed Univ, Inst Fundamental Med & Biol, 18 Kremlyovskaya St, Kazan 420008, Russia
Ishkaeva, Rezeda A. A.
[1
,2
]
Khaertdinov, Nail N. N.
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Kazan Volga Reg Fed Univ, Inst Fundamental Med & Biol, 18 Kremlyovskaya St, Kazan 420008, RussiaKazan Volga Reg Fed Univ, Inst Fundamental Med & Biol, 18 Kremlyovskaya St, Kazan 420008, Russia
Khaertdinov, Nail N. N.
[1
]
Yakovlev, Aleksey V. V.
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Kazan Volga Reg Fed Univ, Inst Fundamental Med & Biol, 18 Kremlyovskaya St, Kazan 420008, RussiaKazan Volga Reg Fed Univ, Inst Fundamental Med & Biol, 18 Kremlyovskaya St, Kazan 420008, Russia
Yakovlev, Aleksey V. V.
[1
]
Esmeteva, Marina V. V.
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Kazan Volga Reg Fed Univ, Inst Fundamental Med & Biol, 18 Kremlyovskaya St, Kazan 420008, Russia
Kazan Volga Reg Fed Univ, Sci & Educ Ctr Pharmaceut, 18 Kremlyovskaya St, Kazan 420008, RussiaKazan Volga Reg Fed Univ, Inst Fundamental Med & Biol, 18 Kremlyovskaya St, Kazan 420008, Russia
Esmeteva, Marina V. V.
[1
,2
]
Salakhieva, Diana V. V.
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Kazan Volga Reg Fed Univ, Inst Fundamental Med & Biol, 18 Kremlyovskaya St, Kazan 420008, Russia
Kazan Volga Reg Fed Univ, Sci & Educ Ctr Pharmaceut, 18 Kremlyovskaya St, Kazan 420008, RussiaKazan Volga Reg Fed Univ, Inst Fundamental Med & Biol, 18 Kremlyovskaya St, Kazan 420008, Russia
Salakhieva, Diana V. V.
[1
,2
]
Nizamov, Ilyas S. S.
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Kazan Volga Reg Fed Univ, Alexander Butlerov Inst Chem, Kazan 420008, Russia
FRC Kazan Sci Ctr RAS, Arbuzov Inst Organ & Phys Chem, 8 Arbuzov St, Kazan 420088, RussiaKazan Volga Reg Fed Univ, Inst Fundamental Med & Biol, 18 Kremlyovskaya St, Kazan 420008, Russia
Nizamov, Ilyas S. S.
[3
,4
]
Sitdikova, Guzel F. F.
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Kazan Volga Reg Fed Univ, Inst Fundamental Med & Biol, 18 Kremlyovskaya St, Kazan 420008, RussiaKazan Volga Reg Fed Univ, Inst Fundamental Med & Biol, 18 Kremlyovskaya St, Kazan 420008, Russia
Sitdikova, Guzel F. F.
[1
]
Abdullin, Timur I. I.
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Kazan Volga Reg Fed Univ, Inst Fundamental Med & Biol, 18 Kremlyovskaya St, Kazan 420008, Russia
Kazan Volga Reg Fed Univ, Sci & Educ Ctr Pharmaceut, 18 Kremlyovskaya St, Kazan 420008, RussiaKazan Volga Reg Fed Univ, Inst Fundamental Med & Biol, 18 Kremlyovskaya St, Kazan 420008, Russia
Abdullin, Timur I. I.
[1
,2
]
机构:
[1] Kazan Volga Reg Fed Univ, Inst Fundamental Med & Biol, 18 Kremlyovskaya St, Kazan 420008, Russia
[2] Kazan Volga Reg Fed Univ, Sci & Educ Ctr Pharmaceut, 18 Kremlyovskaya St, Kazan 420008, Russia
[3] Kazan Volga Reg Fed Univ, Alexander Butlerov Inst Chem, Kazan 420008, Russia
[4] FRC Kazan Sci Ctr RAS, Arbuzov Inst Organ & Phys Chem, 8 Arbuzov St, Kazan 420088, Russia
Considering the important cytoprotective and signaling roles but relatively narrow therapeutic index of hydrogen sulfide (H2S), advanced H2S donors are required to achieve a therapeutic effect. In this study, we proposed glutathione dithiophosphates as new combination donors of H2S and glutathione. The kinetics of H2S formation in dithiophosphate solutions suggested a continuous H2S release by the donors, which was higher for the dithiophosphate of reduced glutathione than oxidized glutathione. The compounds, unlike NaHS, inhibited the proliferation of C2C12 myoblasts at submillimolar concentrations due to an efficient increase in intracellular H2S. The H2S donors more profoundly affected reactive oxygen species and reduced glutathione levels in C2C12 myocytes, in which these parameters were elevated compared to myoblasts. Oxidized glutathione dithiophosphate as well as control donors exerted antioxidant action toward myocytes, whereas the effect of reduced glutathione dithiophosphate at (sub-)micromolar concentrations was rather modulating. This dithiophosphate showed an enhanced negative inotropic effect mediated by H2S upon contraction of the atrial myocardium, furthermore, its activity was prolonged and reluctant for washing. These findings identify glutathione dithiophosphates as redox-modulating H2S donors with long-acting profile, which are of interest for further pharmacological investigation.
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Fudan Univ, Inst Radiat Med, Shanghai 200032, Peoples R ChinaFudan Univ, Inst Radiat Med, Shanghai 200032, Peoples R China
Pan, Yan
Ye, Shuang
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Fudan Univ, Inst Radiat Med, Shanghai 200032, Peoples R ChinaFudan Univ, Inst Radiat Med, Shanghai 200032, Peoples R China
Ye, Shuang
Yuan, Dexiao
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Fudan Univ, Inst Radiat Med, Shanghai 200032, Peoples R ChinaFudan Univ, Inst Radiat Med, Shanghai 200032, Peoples R China
Yuan, Dexiao
Zhang, Jianghong
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Fudan Univ, Inst Radiat Med, Shanghai 200032, Peoples R ChinaFudan Univ, Inst Radiat Med, Shanghai 200032, Peoples R China
Zhang, Jianghong
Bai, Yang
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Fudan Univ, Inst Radiat Med, Shanghai 200032, Peoples R ChinaFudan Univ, Inst Radiat Med, Shanghai 200032, Peoples R China
Bai, Yang
Shao, Chunlin
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Fudan Univ, Inst Radiat Med, Shanghai 200032, Peoples R China
Anhui Med Univ, Sch Med Sci, Div Nucl Med, Hefei, Peoples R ChinaFudan Univ, Inst Radiat Med, Shanghai 200032, Peoples R China
机构:
Indiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Univ Notre Dame, Dept Biol Sci, Notre Dame, IN 46556 USAIndiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Olson, Kenneth R.
Clear, Kasey J.
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Indiana Univ South Bend, Dept Chem & Biochem, South Bend, IN 46615 USAIndiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Clear, Kasey J.
Takata, Tsuyoshi
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Indiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Univ Notre Dame, Dept Biol Sci, Notre Dame, IN 46556 USAIndiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Takata, Tsuyoshi
Gao, Yan
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Indiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USAIndiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Gao, Yan
Ma, Zhilin
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Indiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Univ Notre Dame, Dept Biol Sci, Notre Dame, IN 46556 USAIndiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Ma, Zhilin
Pfaff, Ella
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Indiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Univ Notre Dame, Dept Biol Sci, Notre Dame, IN 46556 USAIndiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Pfaff, Ella
Travlos, Anthony
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Indiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Univ Notre Dame, Dept Biol Sci, Notre Dame, IN 46556 USAIndiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Travlos, Anthony
Luu, Jennifer
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Indiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Univ Notre Dame, Dept Biol Sci, Notre Dame, IN 46556 USAIndiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Luu, Jennifer
Wilson, Katherine
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Indiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Univ Notre Dame, Dept Biol Sci, Notre Dame, IN 46556 USAIndiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Wilson, Katherine
Joseph, Zachary
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Indiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Univ Notre Dame, Dept Biol Sci, Notre Dame, IN 46556 USAIndiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Joseph, Zachary
Kyle, Ian
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Indiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Univ Notre Dame, Dept Biol Sci, Notre Dame, IN 46556 USAIndiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Kyle, Ian
Kasko, Stephen M.
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Indiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Univ Notre Dame, Dept Biol Sci, Notre Dame, IN 46556 USAIndiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Kasko, Stephen M.
Jones, Prentiss, Jr.
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Western Mchigan Univ, Homer Stryker M D Sch Med, Toxicol Dept, Kalamazoo, MI 49007 USAIndiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Jones, Prentiss, Jr.
Fukuto, Jon
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Sonoma State Univ, Dept Chem, Rohnert Pk, CA 94928 USAIndiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Fukuto, Jon
Xian, Ming
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Brown Univ, Dept Chem, Providence, RI 02912 USAIndiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Xian, Ming
Wu, Gang
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Univ Texas MD Anderson Canc Ctr, McGovern Med Sch, Dept Internal Med, Houston, TX 77030 USAIndiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Wu, Gang
Straub, Karl D.
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Cent Arkansas Vet Healthcare Syst, Little Rock, AR 72205 USA
Univ Arkansas Med Sci, Dept Med, Little Rock, AR 72202 USA
Univ Arkansas Med Sci, Dept Biochem, Little Rock, AR 72202 USAIndiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
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Guru Nanak Dev Univ, UGC Ctr Adv Studies 2, Dept Chem, Amritsar 143001, Pb, IndiaGuru Nanak Dev Univ, UGC Ctr Adv Studies 2, Dept Chem, Amritsar 143001, Pb, India
Kaur, Rajdeep
Kour, Rasdeep
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Guru Nanak Dev Univ, Dept Bot & Environm Sci, Amritsar 143001, Pb, IndiaGuru Nanak Dev Univ, UGC Ctr Adv Studies 2, Dept Chem, Amritsar 143001, Pb, India
Kour, Rasdeep
Kaur, Satwinderjeet
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Guru Nanak Dev Univ, Dept Bot & Environm Sci, Amritsar 143001, Pb, IndiaGuru Nanak Dev Univ, UGC Ctr Adv Studies 2, Dept Chem, Amritsar 143001, Pb, India
Kaur, Satwinderjeet
Singh, Prabhpreet
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Guru Nanak Dev Univ, UGC Ctr Adv Studies 2, Dept Chem, Amritsar 143001, Pb, IndiaGuru Nanak Dev Univ, UGC Ctr Adv Studies 2, Dept Chem, Amritsar 143001, Pb, India
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Fudan Univ, Inst Radiat Med, Shanghai 200032, Peoples R ChinaFudan Univ, Inst Radiat Med, Shanghai 200032, Peoples R China
Pan, Yan
Ye, Shuang
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Fudan Univ, Inst Radiat Med, Shanghai 200032, Peoples R ChinaFudan Univ, Inst Radiat Med, Shanghai 200032, Peoples R China
Ye, Shuang
Yuan, Dexiao
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Fudan Univ, Inst Radiat Med, Shanghai 200032, Peoples R ChinaFudan Univ, Inst Radiat Med, Shanghai 200032, Peoples R China
Yuan, Dexiao
Zhang, Jianghong
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Fudan Univ, Inst Radiat Med, Shanghai 200032, Peoples R ChinaFudan Univ, Inst Radiat Med, Shanghai 200032, Peoples R China
Zhang, Jianghong
Bai, Yang
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Fudan Univ, Inst Radiat Med, Shanghai 200032, Peoples R ChinaFudan Univ, Inst Radiat Med, Shanghai 200032, Peoples R China
Bai, Yang
Shao, Chunlin
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Fudan Univ, Inst Radiat Med, Shanghai 200032, Peoples R China
Anhui Med Univ, Sch Med Sci, Div Nucl Med, Hefei, Peoples R ChinaFudan Univ, Inst Radiat Med, Shanghai 200032, Peoples R China
机构:
Indiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Univ Notre Dame, Dept Biol Sci, Notre Dame, IN 46556 USAIndiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Olson, Kenneth R.
Clear, Kasey J.
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h-index: 0
机构:
Indiana Univ South Bend, Dept Chem & Biochem, South Bend, IN 46615 USAIndiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Clear, Kasey J.
Takata, Tsuyoshi
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Indiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Univ Notre Dame, Dept Biol Sci, Notre Dame, IN 46556 USAIndiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Takata, Tsuyoshi
Gao, Yan
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Indiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USAIndiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Gao, Yan
Ma, Zhilin
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h-index: 0
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Indiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Univ Notre Dame, Dept Biol Sci, Notre Dame, IN 46556 USAIndiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Ma, Zhilin
Pfaff, Ella
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Indiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Univ Notre Dame, Dept Biol Sci, Notre Dame, IN 46556 USAIndiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Pfaff, Ella
Travlos, Anthony
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Indiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Univ Notre Dame, Dept Biol Sci, Notre Dame, IN 46556 USAIndiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Travlos, Anthony
Luu, Jennifer
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Indiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Univ Notre Dame, Dept Biol Sci, Notre Dame, IN 46556 USAIndiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Luu, Jennifer
Wilson, Katherine
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Indiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Univ Notre Dame, Dept Biol Sci, Notre Dame, IN 46556 USAIndiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Wilson, Katherine
Joseph, Zachary
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Indiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Univ Notre Dame, Dept Biol Sci, Notre Dame, IN 46556 USAIndiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Joseph, Zachary
Kyle, Ian
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机构:
Indiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Univ Notre Dame, Dept Biol Sci, Notre Dame, IN 46556 USAIndiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Kyle, Ian
Kasko, Stephen M.
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h-index: 0
机构:
Indiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Univ Notre Dame, Dept Biol Sci, Notre Dame, IN 46556 USAIndiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Kasko, Stephen M.
Jones, Prentiss, Jr.
论文数: 0引用数: 0
h-index: 0
机构:
Western Mchigan Univ, Homer Stryker M D Sch Med, Toxicol Dept, Kalamazoo, MI 49007 USAIndiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Jones, Prentiss, Jr.
Fukuto, Jon
论文数: 0引用数: 0
h-index: 0
机构:
Sonoma State Univ, Dept Chem, Rohnert Pk, CA 94928 USAIndiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Fukuto, Jon
Xian, Ming
论文数: 0引用数: 0
h-index: 0
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Brown Univ, Dept Chem, Providence, RI 02912 USAIndiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Xian, Ming
Wu, Gang
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h-index: 0
机构:
Univ Texas MD Anderson Canc Ctr, McGovern Med Sch, Dept Internal Med, Houston, TX 77030 USAIndiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
Wu, Gang
Straub, Karl D.
论文数: 0引用数: 0
h-index: 0
机构:
Cent Arkansas Vet Healthcare Syst, Little Rock, AR 72205 USA
Univ Arkansas Med Sci, Dept Med, Little Rock, AR 72202 USA
Univ Arkansas Med Sci, Dept Biochem, Little Rock, AR 72202 USAIndiana Univ, Sch Med, South Bend Ctr, Dept Physiol, South Bend, IN 46617 USA
机构:
Guru Nanak Dev Univ, UGC Ctr Adv Studies 2, Dept Chem, Amritsar 143001, Pb, IndiaGuru Nanak Dev Univ, UGC Ctr Adv Studies 2, Dept Chem, Amritsar 143001, Pb, India
Kaur, Rajdeep
Kour, Rasdeep
论文数: 0引用数: 0
h-index: 0
机构:
Guru Nanak Dev Univ, Dept Bot & Environm Sci, Amritsar 143001, Pb, IndiaGuru Nanak Dev Univ, UGC Ctr Adv Studies 2, Dept Chem, Amritsar 143001, Pb, India
Kour, Rasdeep
Kaur, Satwinderjeet
论文数: 0引用数: 0
h-index: 0
机构:
Guru Nanak Dev Univ, Dept Bot & Environm Sci, Amritsar 143001, Pb, IndiaGuru Nanak Dev Univ, UGC Ctr Adv Studies 2, Dept Chem, Amritsar 143001, Pb, India
Kaur, Satwinderjeet
Singh, Prabhpreet
论文数: 0引用数: 0
h-index: 0
机构:
Guru Nanak Dev Univ, UGC Ctr Adv Studies 2, Dept Chem, Amritsar 143001, Pb, IndiaGuru Nanak Dev Univ, UGC Ctr Adv Studies 2, Dept Chem, Amritsar 143001, Pb, India