Allogeneic hematopoietic stem cell transplantation for NK/T-cell lymphoma: an international collaborative analysis

被引：18

作者：

Berning, Philipp ^{[1
]}

Schmitz, Norbert ^{[1
]}

Ngoya, Maud ^{[2
]}

Finel, Herve ^{[2
]}

Boumendil, Ariane ^{[2
]}

Wang, Fengrong ^{[3
]}

Huang, Xiao-Jun ^{[3
]}

Hermine, Olivier ^{[4
]}

Philippe, Laure ^{[4
]}

Couronne, Lucile ^{[5
]}

Jaccard, Arnaud ^{[6
]}

Liu, Daihong ^{[7
]}

Wu, Depei ^{[8
]}

Reinhardt, Hans Christian ^{[9
]}

Chalandon, Yves ^{[10
,11
]}

Wagner-Drouet, Eva

Kwon, Mi

Zhang, Xi

Carpenter, Ben

Yakoub-Agha, Ibrahim

Wulf, Gerald

Lopez-Jimenez, Javier

Sanz, Jaime

Labussiere-Wallet, Helene

Shimoni, Avichai

Dreger, Peter

Sureda, Anna

Kim, Won Seog

Glass, Bertram

机构：

[1] Univ Hosp Muenster, Dept Hematol & Oncol, Munster, Germany

[2] Hop St Antoine, European Soc Blood & Marrow Transplantat, Paris, France

[3] Beijing Univ, Inst Hematol, Natl Clin Res Ctr Hematol Dis, Beijing, Peoples R China

[4] Univ Paris 05, Hop Necker, AP HP, Dept Hematol, Paris, France

[5] Univ Paris Cite, Necker Childrens Hosp, APHP, Lab Oncohematol, Paris, France

[6] CHU Dupuytren, Dept Hematol, Limoges, France

[7] Gen Hosp Peoples Liberat Army China, Beijing, Peoples R China

[8] Soochow Univ, Jiangsu Inst Hematol, Natl Clin Res Ctr Hematol Dis, Affiliated Hosp 1, Suzhou, Peoples R China

[9] Univ Duisburg Essen, Univ Hosp Essen, Dept Hematol & Stem Cell Transplantat, Essen, Germany

[10] Univ Geneva, Hop Univ Geneve, Div Hematol, Geneva, Switzerland

[11] Univ Geneva, Fac Med, Geneva, Switzerland

来源：

LEUKEMIA | 2023年 / 37卷 / 07期

关键词：

MATURE T-CELL; NASAL-TYPE; RETROSPECTIVE ANALYSIS; MULTICENTER; CHEMOTHERAPY; OUTCOMES; SMILE; GUIDELINES; DIAGNOSIS; BLOCKADE;

D O I：

10.1038/s41375-023-01924-x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Natural killer/T-cell lymphomas (NKTCL) represent rare and aggressive lymphoid malignancies. Patients (pts) with relapsed/refractory disease after Asparaginase (ASPA)-based chemotherapy have a dismal prognosis. To better define the role of allogeneic hematopoietic stem cell transplantation (allo-HSCT), we conducted a retrospective analysis of data shared with the European Society for Blood and Marrow Transplantation (EBMT) and cooperating Asian centers. We identified 135 pts who received allo-HSCT between 2010 and 2020. Median age was 43.4 years at allo-HSCT, 68.1% were male. Ninety-seven pts (71.9 %) were European, 38 pts (28.1%) Asian. High Prognostic Index for NKTCL (PINK) scores were reported for 44.4%; 76.3% had >1 treatment, 20.7% previous auto-HSCT, and 74.1% ASPA-containing regimens prior to allo-HSCT. Most (79.3%) pts were transplanted in CR/PR. With a median follow-up of 4.8 years, 3-year progression-free(PFS) and overall survival were 48.6% (95%-CI:39.5-57%) and 55.6% (95%-CI:46.5-63.8%). Non-relapse mortality at 1 year was 14.8% (95%-CI:9.3-21.5%) and 1-year relapse incidence 29.6% (95%-CI:21.9-37.6%). In multivariate analyses, shorter time interval (0-12 months) between diagnosis and allo-HSCT [HR = 2.12 (95%-CI:1.03-4.34); P = 0.04] and transplantation not in CR/PR [HR = 2.20 (95%-CI:0.98-4.95); P = 0.056] reduced PFS. Programmed cell death protein 1(PD-1/PD-L1) treatment before HSCT neither increased GVHD nor impacted survival. We demonstrate that allo-HSCT can achieve long-term survival in approximately half of pts allografted for NKTCL.

引用

页码：1511 / 1520

页数：10

共 40 条

[1] The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms [J].

Alaggio, Rita ;

Amador, Catalina ;

Anagnostopoulos, Ioannis ;

Attygalle, Ayoma D. ;

Araujo, Iguaracyra Barreto de Oliveira ;

Berti, Emilio ;

Bhagat, Govind ;

Borges, Anita Maria ;

Boyer, Daniel ;

Calaminici, Mariarita ;

Chadburn, Amy ;

Chan, John K. C. ;

Cheuk, Wah ;

Chng, Wee-Joo ;

Choi, John K. ;

Chuang, Shih-Sung ;

Coupland, Sarah E. ;

Czader, Magdalena ;

Dave, Sandeep S. ;

de Jong, Daphne ;

Du, Ming-Qing ;

Elenitoba-Johnson, Kojo S. ;

Ferry, Judith ;

Geyer, Julia ;

Gratzinger, Dita ;

Guitart, Joan ;

Gujral, Sumeet ;

Harris, Marian ;

Harrison, Christine J. ;

Hartmann, Sylvia ;

Hochhaus, Andreas ;

Jansen, Patty M. ;

Karube, Kennosuke ;

Kempf, Werner ;

Khoury, Joseph ;

Kimura, Hiroshi ;

Klapper, Wolfram ;

Kovach, Alexandra E. ;

Kumar, Shaji ;

Lazar, Alexander J. ;

Lazzi, Stefano ;

Leoncini, Lorenzo ;

Leung, Nelson ;

Leventaki, Vasiliki ;

Li, Xiao-Qiu ;

Lim, Megan S. ;

Liu, Wei-Ping ;

Louissaint, Abner, Jr. ;

Marcogliese, Andrea ;

Medeiros, L. Jeffrey .

LEUKEMIA, 2022, 36 (07) :1720-1748

[2] Defining the Intensity of Conditioning Regimens: Working Definitions [J].

Bacigalupo, Andrea ;

Ballen, Karen ;

Rizzo, Doug ;

Giralt, Sergio ;

Lazarus, Hillard ;

Ho, Vincent ;

Apperley, Jane ;

Slavin, Shimon ;

Pasquini, Marcelo ;

Sandmaier, Brenda M. ;

Barrett, John ;

Blaise, Didier ;

Lowski, Robert ;

Horowitz, Mary .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2009, 15 (12) :1628-1633

[3] Use of checkpoint inhibitors in patients with lymphoid malignancies receiving allogeneic cell transplantation: a review [J].

Bobillo, Sabela ;

Camilo Nieto, Juan ;

Barba, Pere .

BONE MARROW TRANSPLANTATION, 2021, 56 (08) :1784-1793

[4] Allogeneic stem cell transplantation in poor prognosis peripheral T-cell lymphoma: the impact of different donor type on outcome [J].

Castagna, Luca ;

Pagliardini, Thomas ;

Bramanti, Stefania ;

Schiano de Colella, Jean Marc ;

Montes de Oca, Catalina ;

Bouabdallah, Reda ;

Mariotti, Jacopo ;

Furst, Sabine ;

Granata, Angela ;

De Philippis, Chiara ;

Harbi, Samia ;

Sarina, Barbara ;

Legrand, Faezeh ;

Maisano, Valerio ;

Weiller, Pierre Jean ;

Chabannon, Christian ;

Carlo-Stella, Carmelo ;

Santoro, Armando ;

Blaise, Didier ;

Devillier, Raynier .

BONE MARROW TRANSPLANTATION, 2021, 56 (04) :883-889

[5] Autologous and Allogeneic Stem-Cell Transplantation for Transformed Chronic Lymphocytic Leukemia (Richter's Syndrome): A Retrospective Analysis From the Chronic Lymphocytic Leukemia Subcommittee of the Chronic Leukemia Working Party and Lymphoma Working Party of the European Group for Blood and Marrow Transplantation [J].

Cwynarski, Kate ;

van Biezen, Anja ;

de Wreede, Liesbeth ;

Stilgenbauer, Stephan ;

Bunjes, Donald ;

Metzner, Bernd ;

Koza, Vladimir ;

Mohty, Mohamad ;

Remes, Kari ;

Russell, Nigel ;

Nagler, Arnon ;

Scholten, Marijke ;

de Witte, Theo ;

Sureda, Anna ;

Dreger, Peter .

JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (18) :2211-2217

[6] Peripheral T-cell lymphomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-upaEuro [J].

d'Amore, F. ;

Gaulard, P. ;

Truemper, L. ;

Corradini, P. ;

Kim, W. -S. ;

Specht, L. ;

Pedersen, M. Bjerregaard ;

Ladetto, M. .

ANNALS OF ONCOLOGY, 2015, 26 :V108-V115

[7] Allogeneic hematopoietic stem cell transplantation for advanced extranodal natural killer/T-cell lymphoma, nasal type [J].

Ennishi, Daisuke ;

Maeda, Yoshinobu ;

Fujii, Nobuharu ;

Kondo, Eisei ;

Shinagawa, Katsuji ;

Ikeda, Kazuma ;

Ichimura, Koichi ;

Yoshino, Tadashi ;

Tanimoto, Mitsune .

LEUKEMIA & LYMPHOMA, 2011, 52 (07) :1255-1261

[8] Outcome of allogeneic transplantation for mature T-cell lymphomas: impact of donor source and disease characteristics [J].

Hamadani, Mehdi ;

Ngoya, Maud ;

Sureda, Anna ;

Bashir, Qaiser ;

Litovich, Carlos Alejandro ;

Finel, Herve ;

Chen, Yue ;

Boumendil, Ariane ;

Zain, Jasmine ;

Castagna, Luca ;

Cashen, Amanda F. ;

Blaise, Didier ;

Shadman, Mazyar ;

Pastano, Rocco ;

Khimani, Farhad ;

Arat, Mutlu ;

Dietrich, Sascha ;

Schmitz, Norbert ;

Glass, Bertram ;

Kharfan-Dabaja, Mohamed A. ;

Corradini, Paolo ;

Sauter, Craig S. ;

Montoto, Silvia ;

Kwon, Mi ;

Herrera, Alex F. ;

Dreger, Peter .

BLOOD ADVANCES, 2022, 6 (03) :920-930

[9] PD-1 blockade for relapsed lymphoma post-allogeneic hematopoietic cell transplant: high response rate but frequent GVHD [J].

Haverkos, Bradley M. ;

Abbott, Diana ;

Hamadani, Mehdi ;

Armand, Philippe ;

Flowers, Mary E. ;

Merryman, Reid ;

Kamdar, Manali ;

Kanate, Abraham Sebastian ;

Saad, Ayman ;

Mehta, Amitkumar ;

Ganguly, Siddhartha ;

Fenske, Timothy S. ;

Hari, Parameswaran ;

Lowsky, Robert ;

Andritsos, Leslie ;

Jagasia, Madan ;

Bashey, Asad ;

Brown, Stacey ;

Bachanova, Veronika ;

Stephens, Deborah ;

Mineishi, Shin ;

Nakamura, Ryotaro ;

Chen, Yi-Bin ;

Blazar, Bruce R. ;

Gutman, Jonathan ;

Devine, Steven M. .

BLOOD, 2017, 130 (02) :221-228

[10] Efficacy and tolerability of nivolumab after allogeneic transplantation for relapsed Hodgkin lymphoma [J].

Herbaux, Charles ;

Gauthier, Jordan ;

Brice, Pauline ;

Drumez, Elodie ;

Ysebaert, Loic ;

Doyen, Helene ;

Fornecker, Luc ;

Bouabdallah, Krimo ;

Manson, Guillaume ;

Ghesquieres, Herve ;

Tabrizi, Reza ;

Hermet, Eric ;

Lazarovici, Julien ;

Thiebaut-Bertrand, Anne ;

Chauchet, Adrien ;

Demarquette, Helene ;

Boyle, Eileen ;

Houot, Roch ;

Yakoub-Agha, Ibrahim ;

Morschhauser, Franck .

BLOOD, 2017, 129 (18) :2471-2478

← 1 2 3 4 →