Treatment of eosinophilic esophagitis - advancements andperspectives

被引：0

作者：

Miehlke, Stephan ^{[1
,2
]}

Arnim, Ulrike von ^{[3
]}

Schlag, Christoph ^{[4
]}

Labenz, Joachim ^{[5
]}

Madisch, Ahmed ^{[6
]}

机构：

[1] Magen Darm Zent, Facharztzentrum Eppendorf, Hamburg, Germany

[2] Univ Klinikum Hamburg Eppendorf, Hamburg, Germany

[3] Univ Klinikum Magdeburg AoR, Dept Gastroenterol Hepatol & Infect Dis, Magdeburg, Germany

[4] Tech Univ Munich, Med Dept 2, Klinikum Rechts Isar, Munich, Germany

[5] Ev Jung Stilling Krankenhaus, Med Klin, Siegen, Germany

[6] Siloah Hosp, Dept Internal Med, Hannover, Germany

来源：

LARYNGO-RHINO-OTOLOGIE | 2023年 / 102卷 / 05期

关键词：

eosinophilic esophagitis; topical corticosteroids; budesonide; fluticasone; proton pump inhibitor; elimination diet; biological; BUDESONIDE ORAL SUSPENSION; HISTOLOGIC REMISSION; NATURAL-HISTORY; ADULT PATIENTS; EFFICACY; GUIDELINES; MANAGEMENT; CHILDREN; PLACEBO; DIAGNOSIS;

D O I：

10.1055/a-1861-7152

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

In recent years significant progress has been made in the treatment of eosinophilic esophagitis (EoE), especially in the area of topical corticosteroids. Novel EoE-specific formulations have been developed and first approvals have been obtained for induction and maintenance of remission in adult EoE patients with the orodispersible budesonide tablet in Germany and other European and non-EU countries. A novel budesonide oral suspension is currently under priority review by the FDA for first approval in the U.S. In contrast, the scientific evidence on the efficacy of proton pump inhibitors remains limited. Moreover, new biologicals have been identified which showed promising results in phase 2 trials and are now being studied in phase 3. This article aims to summarize and discuss recent advances and perspectives in the treatment of EoE.

引用

页码：339 / 348

页数：10

共 55 条

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