Urocortin stimulates the ERK1/2 signaling pathway and the proliferation of HeLa cells via CRF receptor 1

被引:0
作者
Balogh, Balint [1 ,2 ]
Vecsernyes, Monika [1 ,2 ,3 ]
Stayer-Harci, Alexandra [1 ,2 ,3 ]
Berta, Gergely [1 ,2 ,3 ]
Tarjanyi, Oktavia [1 ,2 ,3 ]
Setalo, Gyorgy, Jr. [1 ,2 ,3 ]
机构
[1] Univ Pecs, Med Sch, Dept Med Biol, Pecs, Hungary
[2] Univ Pecs, Med Sch, Cent Electron Microscope Lab, Pecs, Hungary
[3] Janos Szentagothai Res Ctr, Signal Transduct Res Grp, Pecs, Hungary
来源
FEBS OPEN BIO | 2023年 / 13卷 / 05期
关键词
cell proliferation; E2F-1; ERK1/2; MEK; HeLa; urocortin; CORTICOTROPIN-RELEASING-FACTOR; ADENYLATE-CYCLASE ACTIVITY; REPERFUSION INJURY; HORMONE-RECEPTOR; POTENTIAL ROLE; MESSENGER-RNA; EXPRESSION; APOPTOSIS; PROTEIN; FAMILY;
D O I
10.1002/2211-5463.13602
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Corticotropin-releasing factor (CRF) stimulates adrenocorticotropic hormone (ACTH) secretion from the pituitary gland and is an essential regulator of the hypothalamic-pituitary-adrenocortical axis. Isoforms of CRF receptor are known to mediate the effects of urocortin stress ligands on the regulation of stress responses, anxiety, and feeding behavior; however, urocortin stress ligands also influence cell proliferation. In view of the tumor-promoting capacity of prolonged stress, here we investigated (a) the effect of urocortin on cell proliferative signaling via extracellular signal-regulated kinase 1/2, (b) the expression and cellular distribution of the specific CRF receptor isoforms, and (c) the intracellular localization of phosphorylated ERK1/2 in HeLa cells. Stimulation of cell proliferation was observed in the presence of 10 nm urocortin. Our data also suggest that MAP kinase MEK, the transcription factors E2F-1 and p53, and PKB/Akt are involved in this process. These findings may have therapeutic relevance for the targeted treatment of various malignancies.
引用
收藏
页码:818 / 832
页数:15
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