Process Simulation of Twin-Screw Granulator: Effect of Screw Configuration on Size Distribution

被引：2

作者：

Arthur, Tony B. ^{[1
]}

Sekyi, Nana K. G. ^{[1
]}

Rahmanian, Nejat ^{[1
]}

Pu, Jaan ^{[1
]}

机构：

[1] Univ Bradford, Fac Engn & Informat, Dept Chem Engn, Bradford BD7 1DP, England

来源：

CHEMICAL ENGINEERING & TECHNOLOGY | 2023年 / 46卷 / 06期

关键词：

Agglomerates; Granule size distribution; Kneading elements; Liquid-to-solid ratio; Twin-screw granulator; WET GRANULATION; LAYERING MECHANISM; PARAMETERS; GROWTH; DESIGN; MODEL;

D O I：

10.1002/ceat.202200539

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

The effect of screw configuration on granule size distribution (GSD) using gPROMS FormulatedProduct (gFP) software to perform optimization, estimation of complex processes, and analyses is evaluated. Twin-screw granulation modeling was used to investigate the contribution of screw configuration and liquid-to-solid (L/S) ratio on GSD. Lactose and Avicel were the granulating materials. Twelve different configurations were investigated under three feed rates as consistent with literature and at various L/S ratios. Results indicate that kneading elements promote the recovery of 100-1000 mu m granules while reducing the production of oversized granules. Higher feed rates support the production of fines and agglomerates, while a low feed rate produces 100-1000 mu m granules.

引用

页码：1251 / 1259

页数：9

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