Radiosynthesis, Preclinical, and Clinical Positron Emission Tomography Studies of Carbon-11 Labeled Endogenous and Natural Exogenous Compounds

被引：11

作者：

Shegani, Antonio ^{[1
]}

Kealey, Steven ^{[1
]}

Luzi, Federico ^{[1
]}

Basagni, Filippo ^{[2
]}

Machado, Joana do Mar ^{[1
]}

Ekici, Sevban Dogan ^{[1
]}

Ferocino, Alessandra ^{[3
]}

Gee, Antony D. ^{[1
]}

Bongarzone, Salvatore ^{[1
,4
]}

机构：

[1] Kings Coll London, Sch Biomed Engn & Imaging Sci, Kings Hlth Partners, London SE1 7EH, England

[2] Alma Mater Studiorum Univ Bologna, Dept Pharm & Biotechnol, I-40126 Bologna, Italy

[3] Italian Natl Res Council, Inst Organ Synth & Photoreact, I-40129 Bologna, Italy

[4] Novartis Co, Tech Res & Dev Adv Accelerator Applicat, Via Ribes 5, I-10010 Colleretto Giacosa, Italy

来源：

CHEMICAL REVIEWS | 2023年 / 123卷 / 01期

基金：

英国工程与自然科学研究理事会;

关键词：

CEREBRAL PROTEIN-SYNTHESIS; BLOOD-BRAIN-BARRIER; HIGH-YIELD SYNTHESIS; IN-VIVO MEASUREMENT; SQUAMOUS-CELL CARCINOMA; CARRIER-ADDED SYNTHESIS; POTENTIAL PET TRACER; TNF-ALPHA PRODUCTION; MONOAMINE OXIDASE-A; TISSUE AMINO-ACIDS;

D O I：

10.1021/acs.chemrev.2c00398

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The presence of positron emission tomography (PET) centers at most major hospitals worldwide, along with the improvement of PET scanner sensit i v i t y and the introduction of total body PET systems, has increased the interest in the PET tracer development using the short-lived radionuclides carbon-11. In the last few decades, methodological improvements and fully automated modules have allowed the development of carbon-11 tracers for clinical use. Radiolabeling natural compounds with carbon-11 by substituting one of the backbone carbons with the radionuclide has provided important information on the biochemistry of the authentic compounds and increased the understanding of their in vivo behavior in healthy and diseased states. The number of endogenous and natural compounds essential for human life is staggering, ranging from simple alcohols to vitamins and peptides. This review collates all the carbon-11 radiolabeled endogenous and natural exogenous compounds synthesised to date, including essential information on thei r radiochemistry methodologies and preclinical and clinical studies in healthy subjects.

引用

页码：105 / 229

页数：125