Metabolic Engineering of Bacillus subtilis for Riboflavin Production: A Review

被引：9
作者：
Liu, Yang [1 ,2 ]
Zhang, Quan [1 ]
Qi, Xiaoxiao [2 ,3 ]
Gao, Huipeng [1 ]
Wang, Meng [1 ]
Guan, Hao [1 ]
Yu, Bo [2 ]
机构：
[1] SINOPEC Dalian Res Inst Petr & Petro Chem Co Ltd, Key Lab Biofuels & Biochem Engn, Dalian 116045, Peoples R China
[2] Chinese Acad Sci, Inst Microbiol, CAS Key Lab Microbial Physiol & Metab Engn, State Key Lab Mycol, Beijing 100101, Peoples R China
[3] Univ Chinese Acad Sci, Sch Life Sci, Beijing 100049, Peoples R China
来源：
MICROORGANISMS | 2023年 / 11卷 / 01期
基金：
北京市自然科学基金;
关键词：
riboflavin; biosynthesis; Bacillus subtilis; metabolic engineering; PURINE BIOSYNTHESIS; EXPRESSION SYSTEM; RESISTANT MUTANTS; ESCHERICHIA-COLI; GENETIC-CONTROL; RNA STRUCTURE; OPERON; STRAIN; REDUCTASE; DEAMINASE;
D O I：
10.3390/microorganisms11010164
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Riboflavin (vitamin B-2) is one of the essential vitamins that the human body needs to maintain normal metabolism. Its biosynthesis has become one of the successful models for gradual replacement of traditional chemical production routes. B. subtilis is characterized by its short fermentation time and high yield, which shows a huge competitive advantage in microbial fermentation for production of riboflavin. This review summarized the advancements of regulation on riboflavin production as well as the synthesis of two precursors of ribulose-5-phosphate riboflavin (Ru5P) and guanosine 5 '-triphosphate (GTP) in B. subtilis. The different strategies to improve production of riboflavin by metabolic engineering were also reviewed.
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页数：15
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