Pancreatic ductal adenocarcinoma: tumor microenvironment and problems in the development of novel therapeutic strategies

被引：14
作者：
Kuznetsova, Alla [1 ,2 ]
Popova, Olga [1 ]
Panchenkov, Dmitry [1 ]
Dyuzheva, Tatyana [3 ]
Ivanov, Alexey [1 ]
机构：
[1] AI Evdokimov Moscow State Univ Med & Dent, Minist Hlth Russian Federat, 20,Bld 1,Delegatskaya St, Moscow 127473, Russia
[2] Russian Acad Sci, Koltzov Inst Dev Biol, 26 Vavilov St, Moscow 119334, Russia
[3] IM Sechenov First Moscow State Med Univ, Sechenov Univ, Minist Hlth Russian Federat, 8-2 Trubetskaya St, Moscow 119991, Russia
来源：
CLINICAL AND EXPERIMENTAL MEDICINE | 2023年 / 23卷 / 03期
关键词：
Tumor microenvironment; Extracellular matrix; Cancer-associated fibroblasts; CAF heterogeneity; Pancreatic ductal adenocarcinoma; Stromal targeting; CARCINOMA-ASSOCIATED FIBROBLASTS; CANCER-ASSOCIATED FIBROBLASTS; PAPILLARY-MUCINOUS NEOPLASMS; FOCAL ADHESION KINASE; STELLATE CELLS; TGF-BETA; ANGIOTENSIN SYSTEM; GROWTH-FACTOR; SLIT-ROBO; RECEPTOR;
D O I：
10.1007/s10238-022-00886-1
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Diagnosis and treatment of carcinoma of the exocrine part of the pancreas is a serious problem for modern medicine. Despite the identification of a large number of aberrant mutations in pancreatic ductal adenocarcinoma (PDAC), attempts to create effective therapeutic agents based on identified genetic or epigenetic variations have not been succesful. The role of the tumor microenvironment (TME) in tumor progression is currently a popular topic. Cancer-associated fibroblasts (CAFs) and extracellular matrix (ECM) are the main components of the tumor stroma and play an important role in the proliferation, invasiveness and metastasis of cancer. However, the mechanisms underlying the effect of CAFs and ECM on cancer progression are still unclear. Recent studies on stromal components and blockage of signaling pathways have brought some optimism to this area. New information on the role of TME will lead to the development of targeted therapies or combinations with modern chemotherapy for PDAC.
引用
收藏
页码：619 / 643
页数：25
相关论文
共 150 条
[41]   Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors [J].
Diop-Frimpong, Benjamin ;
Chauhan, Vikash P. ;
Krane, Stephen ;
Boucher, Yves ;
Jain, Rakesh K. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (07) :2909-2914
[42]   Mounting Pressure in the Microenvironment: Fluids, Solids, and Cells in Pancreatic Ductal Adenocarcinoma [J].
DuFort, Christopher C. ;
DelGiorno, Kathleen E. ;
Hingorani, Sunil R. .
GASTROENTEROLOGY, 2016, 150 (07) :1545-+
[43]   Dynamic interplay between the collagen scaffold and tumor evolution [J].
Egeblad, Mikala ;
Rasch, Morten G. ;
Weaver, Valerie M. .
CURRENT OPINION IN CELL BIOLOGY, 2010, 22 (05) :697-706
[44]   Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts [J].
Elyada, Ela ;
Bolisetty, Mohan ;
Laise, Pasquale ;
Flynn, William F. ;
Courtois, Elise T. ;
Burkhart, Richard A. ;
Teinor, Jonathan A. ;
Belleau, Pascal ;
Biffi, Giulia ;
Lucito, Matthew S. ;
Sivajothi, Santhosh ;
Armstrong, Todd D. ;
Engle, Dannielle D. ;
Yu, Kenneth H. ;
Hao, Yuan ;
Wolfgang, Christopher L. ;
Park, Youngkyu ;
Preall, Jonathan ;
Jaffee, Elizabeth M. ;
Califano, Andrea ;
Robson, Paul ;
Tuveson, David A. .
CANCER DISCOVERY, 2019, 9 (08) :1102-1123
[45]   Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin [J].
Erdogan, Begum ;
Ao, Mingfang ;
White, Lauren M. ;
Means, Anna L. ;
Brewer, Bryson M. ;
Yang, Lijie ;
Washington, M. Kay ;
Shi, Chanjuan ;
Franco, Omar E. ;
Weaver, Alissa M. ;
Hayward, Simon W. ;
Li, Deyu ;
Webb, Donna J. .
JOURNAL OF CELL BIOLOGY, 2017, 216 (11) :3799-3816
[46]   Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors [J].
Escot, Sophie ;
Willnow, David ;
Naumann, Heike ;
Di Francescantonio, Silvia ;
Spagnoli, Francesca M. .
NATURE COMMUNICATIONS, 2018, 9
[47]   The tumour microenvironment and immune milieu of cholangiocarcinoma [J].
Fabris, Luca ;
Perugorria, Maria J. ;
Mertens, Joachim ;
Bjorkstrom, Niklas K. ;
Cramer, Thorsten ;
Lleo, Ana ;
Solinas, Antonio ;
Saenger, Hanna ;
Lukacs-Kornek, Veronika ;
Moncsek, Anja ;
Siebenhuner, Alexander ;
Strazzabosco, Mario .
LIVER INTERNATIONAL, 2019, 39 :63-78
[48]   Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: A new paradigm for combination therapy in solid cancers [J].
Feldmann, Georg ;
Dhara, Surajit ;
Fendrich, Volker ;
Bedja, Djahida ;
Beaty, Robert ;
Mullendore, Michael ;
Karikari, Collins ;
Alvarez, Hector ;
Iacobuzio-Donahue, Christine ;
Jimeno, Antonio ;
Gabrielson, Kathleen L. ;
Matsui, William ;
Maitra, Anirban .
CANCER RESEARCH, 2007, 67 (05) :2187-2196
[49]   The Extracellular Matrix in Pancreatic Cancer: Description of a Complex Network and Promising Therapeutic Options [J].
Ferrara, Benedetta ;
Pignatelli, Cataldo ;
Cossutta, Melissande ;
Citro, Antonio ;
Courty, Jose ;
Piemonti, Lorenzo .
CANCERS, 2021, 13 (17)
[50]   The immune contexture in cancer prognosis and treatment [J].
Fridman, Wolf H. ;
Zitvogel, Laurence ;
Sautes-Fridman, Catherine ;
Kroemer, Guido .
NATURE REVIEWS CLINICAL ONCOLOGY, 2017, 14 (12) :717-734
12345678910