Pancreatic ductal adenocarcinoma: tumor microenvironment and problems in the development of novel therapeutic strategies

被引：14

作者：

Kuznetsova, Alla ^{[1
,2
]}

Popova, Olga ^{[1
]}

Panchenkov, Dmitry ^{[1
]}

Dyuzheva, Tatyana ^{[3
]}

Ivanov, Alexey ^{[1
]}

机构：

[1] AI Evdokimov Moscow State Univ Med & Dent, Minist Hlth Russian Federat, 20,Bld 1,Delegatskaya St, Moscow 127473, Russia

[2] Russian Acad Sci, Koltzov Inst Dev Biol, 26 Vavilov St, Moscow 119334, Russia

[3] IM Sechenov First Moscow State Med Univ, Sechenov Univ, Minist Hlth Russian Federat, 8-2 Trubetskaya St, Moscow 119991, Russia

来源：

CLINICAL AND EXPERIMENTAL MEDICINE | 2023年 / 23卷 / 03期

关键词：

Tumor microenvironment; Extracellular matrix; Cancer-associated fibroblasts; CAF heterogeneity; Pancreatic ductal adenocarcinoma; Stromal targeting; CARCINOMA-ASSOCIATED FIBROBLASTS; CANCER-ASSOCIATED FIBROBLASTS; PAPILLARY-MUCINOUS NEOPLASMS; FOCAL ADHESION KINASE; STELLATE CELLS; TGF-BETA; ANGIOTENSIN SYSTEM; GROWTH-FACTOR; SLIT-ROBO; RECEPTOR;

D O I：

10.1007/s10238-022-00886-1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Diagnosis and treatment of carcinoma of the exocrine part of the pancreas is a serious problem for modern medicine. Despite the identification of a large number of aberrant mutations in pancreatic ductal adenocarcinoma (PDAC), attempts to create effective therapeutic agents based on identified genetic or epigenetic variations have not been succesful. The role of the tumor microenvironment (TME) in tumor progression is currently a popular topic. Cancer-associated fibroblasts (CAFs) and extracellular matrix (ECM) are the main components of the tumor stroma and play an important role in the proliferation, invasiveness and metastasis of cancer. However, the mechanisms underlying the effect of CAFs and ECM on cancer progression are still unclear. Recent studies on stromal components and blockage of signaling pathways have brought some optimism to this area. New information on the role of TME will lead to the development of targeted therapies or combinations with modern chemotherapy for PDAC.

引用

页码：619 / 643

页数：25

共 150 条

[1] Different patterns of p16INK4A and p53 protein expressions in intraductal papillary-mucinous neoplasms and pancreatic intraepithelial neoplasia [J].