Defining the causes of sporadic Parkinson's disease in the global Parkinson's genetics program (GP2)

被引：12

作者：

Towns, Clodagh ^{[1
]}

Richer, Madeleine ^{[1
]}

Jasaityte, Simona ^{[1
]}

Stafford, Eleanor J. ^{[1
,2
]}

Joubert, Julie ^{[1
]}

Antar, Tarek ^{[3
]}

Martinez-Carrasco, Alejandro ^{[1
,2
]}

Makarious, Mary B. ^{[1
,3
,4
]}

Casey, Bradford ^{[5
,6
]}

Levine, Kristin ^{[7
,8
,9
]}

Leonard, Hampton ^{[3
,7
,8
,9
,10
]}

Pantazis, Caroline B. ^{[4
,7
,8
]}

Screven, Laurel A. ^{[7
,8
]}

Hernandez, Dena G. ^{[3
]}

Wegel, Claire E. ^{[11
]}

Solle, Justin ^{[5
]}

Nalls, Mike A. ^{[3
,4
,7
,8
,9
]}

Blauwendraat, Cornelis ^{[4
,7
,8
,12
]}

Singleton, Andrew B. ^{[3
,7
,8
,13
]}

Tan, Manuela M. X. ^{[14
]}

Iwaki, Hirotaka ^{[3
,7
,8
,9
]}

Morris, Huw R. ^{[1
,2
]}

机构：

[1] UCL, Queen Sq Inst Neurol, Dept Clin & Movement Neurosci, London, England

[2] UCL, London, England

[3] NIA, Mol Genet Sect, Lab Neurogenet, NIH, Bethesda, MD 20892 USA

[4] NIH, Bldg 10, Bethesda, MD 20892 USA

[5] Michael J Fox Fdn Parkinsons Res, Dept Clin Res, New York, NY USA

[6] Michael J Fox Fdn Parkinsons Res, New York, NY USA

[7] NIA, Ctr Alzheimers & Related Dementias CARD, NIH, Bethesda, MD USA

[8] NINDS, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA

[9] Data Tecn Int, Washington, DC USA

[10] NIA, NIH, Bethesda, MD 20892 USA

[11] Indiana Univ Sch Med, Dept Med & Mol Genet, Indianapolis, IN 46202 USA

[12] NIA, Integrat Genom Unit, Lab Neurogenet, NIH, Bethesda, MD 20892 USA

[13] NIA, Bethesda, MD 20892 USA

[14] Oslo Univ Hosp, Dept Neurol, Oslo, Norway

来源：

NPJ PARKINSONS DISEASE | 2023年 / 9卷 / 01期

基金：

美国国家卫生研究院;

关键词：

SMELL IDENTIFICATION TEST; PROGRESSION; SCALE; COHORT;

D O I：

10.1038/s41531-023-00533-w

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The Global Parkinson's Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic and clinical data for use in large-scale analyses to dramatically expand our understanding of the genetic architecture of PD. This report details the workflow for cohort integration into the complex arm of GP2, and together with our outline of the monogenic hub in a companion paper, provides a generalizable blueprint for establishing large scale collaborative research consortia.

引用

页数：6

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