Acid-Catalyzed Highly Enantioselective Synthesis of α-Amino Acid Derivatives from Sulfinamides and Alkynes

被引：3

作者：

Liu, Herui ^{[1
]}

Sun, Guangwu ^{[1
]}

Zhang, Yuchao ^{[2
]}

Li, Yongxi ^{[1
]}

Dong, Baobiao ^{[1
]}

Gao, Bing ^{[1
]}

机构：

[1] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China

[2] Univ Chinese Acad Sci, Inst Basic Med, Canc IBMC Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China

来源：

ORGANIC LETTERS | 2024年 / 26卷 / 08期

基金：

中国国家自然科学基金;

关键词：

ASYMMETRIC HYDROGENATION; YNAMIDES;

D O I：

10.1021/acs.orglett.3c04158

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An enantioselective difunctionalization of activated alkynes using chiral sulfinamide reagents is developed. It is an atom and chirality transfer process that allows for the modular synthesis of optically active alpha-amino acid derivatives under mild conditions. The reaction proceeds through an acid-catalyzed [2,3]-sigmatropic rearrangement mechanism with predictable stereochemistry and a broad scope.

引用

页码：1601 / 1606

页数：6

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