Diorganotin(IV) complexes with hydroxamic acids derivatives of some histone deacetylases inhibitors

被引：2

作者：

Nikolic, Danijela N. ^{[1
,2
]}

Gencic, Marija S. ^{[1
]}

Aksic, Jelena M. ^{[1
]}

Radulovic, Niko S. ^{[1
]}

Dimic, Dusan S. ^{[3
]}

Kaluderovic, Goran N. ^{[2
]}

机构：

[1] Univ Nis, Fac Sci & Math, Dept Chem, Visegradska 33, Nish 18000, Serbia

[2] Univ Appl Sci Merseburg, Dept Engn & Nat Sci, Eberhard Leibnitz Str 2, DE-06217 Merseburg, Germany

[3] Univ Belgrade, Fac Phys Chem, Studentski Trg 12-16, Belgrade 11000, Serbia

来源：

JOURNAL OF THE SERBIAN CHEMICAL SOCIETY | 2023年 / 88卷 / 12期

关键词：

diphenyltin(IV); N-hydroxy-4-phenylbutanamide; N-hydroxy-2-propylpentanamide; spectral characterization; DFT; NBO; EFFECTIVE CORE POTENTIALS; CHAIN FATTY-ACID; MOLECULAR CALCULATIONS;

D O I：

10.2298/JSC230630064N

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Organotin(IV) compounds show great potential as antitumor metal-lodrugs with lower toxicity and higher antiproliferative activity. Histone deacetylases (HDAC) inhibitors are characterised by high bioavailability and low toxicity. In this research, the two novel octahedral organotin(IV) complexes of physiologically active hydroxamate-based ligands, N-hydroxy-4-phenylbutan-amide (HL1) and N-hydroxy-2-propylpentanamide (HL2), have been prepared and characterized using FTIR, 1H-, 13C-and 119Sn-NMR spectroscopy. Particular emphasis was put on the binding characteristics of ligands. The structures were additionally analysed by the density functional theory at B3LYP-D3BJ/6--311++G(d,p)(H,C,N,O)/LanL2DZ(Sn)level. The theoretical IR and NMR spectra were compared to the spectroscopic data, and it was concluded that the predicted structures described well the experimental ones. The stability of different isomers of HL1 and HL2 was assessed by the natural bond orbital analysis, and the importance of intramolecular hydrogen bond was outlined. The interactions between donor atoms and Sn were investigated and correlated with the changes in chemical shift and the wavenumbers of characteristic vibrations.

引用

页码：1319 / 1334

页数：16