Antithrombotic Regimen After Percutaneous Left Atrial Appendage Closure

被引：4

作者：

Ryuzaki, Satoko ^{[1
]}

Kondo, Yusuke ^{[1
,3
]}

Nakano, Miyo ^{[1
]}

Nakano, Masahiro ^{[2
]}

Kajiyama, Takatsugu ^{[2
]}

Ito, Ryo ^{[1
]}

Kitagawa, Mari ^{[1
]}

Sugawara, Masafumi ^{[1
]}

Chiba, Toshinori ^{[1
]}

Yoshino, Yutaka ^{[1
]}

Kobayashi, Yoshio ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Med, Dept Cardiovasc Med, Chiba, Japan

[2] Chiba Univ, Grad Sch Med, Dept Adv Cardiorhythm Therapeut, Chiba, Japan

[3] Chiba Univ, Grad Sch Med, Dept Cardiovasc Med, 1-8-1 Inohana,Chuo Ku, Chiba 2608670, Japan

来源：

CIRCULATION JOURNAL | 2023年 / 87卷 / 12期

关键词：

Left atrial appendage closure; Left atrial appendage occlusion; Nonvalvular atrial fibrillation; Stroke; WATCHMAN; NON-PHARMACOTHERAPY; PREDICTING STROKE; FIBRILLATION; OCCLUSION; DEVICE; DEFINITIONS; PREVENTION; GUIDELINE; THERAPY; RISK;

D O I：

10.1253/circj.CJ-22-0687

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Antithrombotic therapy after left atrial appendage closure (LAAC) in patients at high risk of bleeding remains controversial. We present real-world clinical outcomes of LAAC.Methods and Results: Data from 74 consecutive patients who received LAAC therapy between January 2020 and June 2022 were analyzed. Patients received 1 of 3 antithrombotic therapies according to the bleeding risk category or clinical event. Regimen 1 was based on a prior study, regimen 2 comprised a lower antiplatelet drug dose without dual antiplatelet therapy, and regimen 3 was antiplatelet drug administration for as long as possible to patients with uncontrollable bleeding who were required to stop anticoagulant drugs. Overall, 73 (98.6%) procedures were successful. Of them, 16 (21.9%) patients were selected for regimen 1, 46 (63.0%) for regimen 2, and 11 (15.1%) for regimen 3. Device-related thrombosis (13% vs. 0% vs. 0%, P=0.0257) only occurred with regimen 1. There was no difference in major bleeding event rates (6% vs. 2% vs. 9%, P=0.53).Conclusions: The post-LAAC antithrombotic regimen was modified without major concerns.

引用

页码：1820 / +

页数：10

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