Origanum Compactum Essential Oil Ameliorates Triton WR-1339-Induced Hyperlipidemia in Rats: Chemical Composition and Acute Toxicity

被引：3

作者：

Amssayef, Ayoub ^{[1
]}

Soulaimani, Bouchra ^{[2
]}

Qabouche, Adil ^{[1
]}

Abbad, Abdelaziz ^{[2
]}

Eddouks, Mohamed ^{[1
]}

机构：

[1] Moulay Ismail Univ Meknes, Fac Sci & Tech Errachidia, Team Ethnopharmacol & Pharmacognosy, BP 509, Boutalamine, Errachidia, Morocco

[2] Cadi Ayyad Univ, Fac Sci Semlalia, Labeled Res Unit CNRST 4, Lab Microbial Biotechnol Agrosci & Environm, Marrakech, Morocco

来源：

JOURNAL OF HERBS SPICES AND MEDICINAL PLANTS | 2024年 / 30卷 / 02期

关键词：

Antihyperlipidemic effect; medicinal plants; toxicity; LD50; DENSITY-LIPOPROTEIN-CHOLESTEROL; PLASMA;

D O I：

10.1080/10496475.2023.2269888

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The impact of Origanum compactum essential oil (EO) at 80 mg kg(-1) on Triton WR-1339-induced hyperlipidemia in rats was investigated.The EO's phytochemical composition revealed the predominance of carvacrol (35.71%), p-cymene (13.74%), and carvacrol methyl ether (11.71%). Triton WR-1339 led to elevations in total cholesterol (TC), triglycerides (TGs), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), as well asatherogenic indices encompassing the atherogenic coefficient (AC), Castelli's risk index I (CRI-I), and Castelli's risk index II (CRI-II). Conversely, pretreatment with O. Compactum EO for sevendays exerted a preventive effect against the increase of TC, TGs, LDL-C, VLDL-C, AC, CRI-I.

引用

页码：132 / 144

页数：13

共 39 条

[1] Combination of carvacrol with simvastatin improves the lipid-lowering efficacy and alleviates simvastatin side effects [J].