Polyporus umbellatus polysaccharide iron-based nanocomposite for synergistic M1 polarization of TAMs and combinational anti-breast cancer therapy

被引：9

作者：

Liu, Tingting ^{[1
]}

Liu, Congyan ^{[1
,2
]}

Ge, Chang ^{[1
]}

Jiang, Xi ^{[1
]}

Liu, Yuping ^{[1
,2
]}

Kong, Fei ^{[1
]}

Su, Xiangyu ^{[3
]}

Shi, Jiachen ^{[1
]}

Su, Wenting ^{[1
]}

Li, Xiaoqi ^{[1
,2
]}

Chen, Yan ^{[1
,2
,4
]}

Zhang, Huangqin ^{[1
,2
]}

Ma, Qiuling ^{[1
]}

Qu, Ding ^{[1
,2
,4
]}

机构：

[1] Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Wester, Nanjing 210028, Peoples R China

[2] Jiangsu Prov Acad Tradit Chinese Med, Nanjing 210028, Peoples R China

[3] Southeast Univ, Zhongda Hosp, Sch Med, Dept Oncol, Nanjing 210009, Peoples R China

[4] Jiangsu Prov Acad Chinese Med, 100 Shizi Rd, Nanjing 210028, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2023年 / 251卷

基金：

中国国家自然科学基金;

关键词：

Polyporus umbellatus polysaccharide; Iron -based nanocomposites; Tumor -associated macrophages; M1; polarization; Breast cancer; TUMOR-ASSOCIATED MACROPHAGES; OXIDE NANOPARTICLES; FT-IR; DELIVERY;

D O I：

10.1016/j.ijbiomac.2023.126323

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

M1 polarization of tumor-associated macrophages (TAMs) is a promising approach to breaking through therapeutic barriers imposed by the immunosuppressive tumor microenvironment (TME). As a clinically-used immunopotentiator for cancer patients after chemotherapies; however, the immunomodulatory mechanism and potential of polyporus polysaccharide (PPS) remains unclear. Here, we present mannose-decorated PPSloaded superparamagnetic iron-based nanocomposites (Man/PPS-SPIONs) for synergistic M1 polarization of TAMs and consequent combinational anti-breast cancer therapy. Once internalized by M2-like TAMs, PPS released from Man/PPS-SPIONs induces the M1 polarization via IFN-& gamma; secretion and downstream NF-& kappa;B pathway activating. The SPIONs within the nanocomposites mediate a Fenton reaction, producing OH. and activating the subsequent NF-& kappa;B/MAPK pathway, further facilitating the M1 polarization. The Man/PPS-SPIONs thereby establish a positive feedback loop of M1 polarization driven by the "IFN-& gamma;-Fenton-NF-& kappa;B/MAPK" multi-pathway, leading to a series of anti-tumoral immunologic responses in the TME and holding promising potential in combinational anticancer therapies. Our study offers a new strategy to amplify TME engineering by combinational natural carbohydrate polymers and iron-based materials.

引用

页数：13