KRAS mutation: The booster of pancreatic ductal adenocarcinoma transformation and progression

被引：22
作者：
Zhang, Zining [1 ,2 ]
Zhang, Heng [1 ,2 ]
Liao, Xiang [1 ,2 ]
Tsai, Hsiang-i [1 ,2 ]
机构：
[1] Jiangsu Univ, Inst Med Imaging & Artificial Intelligence, Zhenjiang, Peoples R China
[2] Jiangsu Univ, Affiliated Hosp, Dept Med Imaging, Zhenjiang, Peoples R China
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2023年 / 11卷
基金：
中国国家自然科学基金;
关键词：
PDAC; KRAS mutation; phosphokinase; metabolic reprogramming; therapy resistance; poorer prognosis; MUTANT KRAS; GLUTAMINE-METABOLISM; MOUSE MODEL; CANCER; CELL; INHIBITOR; INITIATION; GLYCOLYSIS; KRAS(G12D); EFFICACY;
D O I：
10.3389/fcell.2023.1147676
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer. It has a poor response to conventional therapy and has an extremely poor 5-year survival rate. PDAC is driven by multiple oncogene mutations, with the highest mutation frequency being observed in KRAS. The KRAS protein, which binds to GTP, has phosphokinase activity, which further activates downstream effectors. KRAS mutation contributes to cancer cell proliferation, metabolic reprogramming, immune escape, and therapy resistance in PDAC, acting as a critical driver of the disease. Thus, KRAS mutation is positively associated with poorer prognosis in pancreatic cancer patients. This review focus on the KRAS mutation patterns in PDAC, and further emphases its role in signal transduction, metabolic reprogramming, therapy resistance and prognosis, hoping to provide KRAS target therapy strategies for PDAC.
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页数：16
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共 160 条
  • [11] Pancreatic cancer cell radiation survival and prenyltransferase inhibition: The role of K-ras
    Brunner, TB
    Cengel, KA
    Hahn, SM
    Wu, HM
    Fraker, DL
    McKenna, WG
    Bernhard, EJ
    [J]. CANCER RESEARCH, 2005, 65 (18) : 8433 - 8441
  • [12] Role of oncogenic KRAS in the diagnosis, prognosis and treatment of pancreatic cancer
    Buscail, Louis
    Bournet, Barbara
    Cordelier, Pierre
    [J]. NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2020, 17 (03) : 153 - 168
  • [13] Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis
    Carrer, Alessandro
    Trefely, Sophie
    Zhao, Steven
    Campbell, Sydney L.
    Norgard, Robert J.
    Schultz, Kollin C.
    Sidoli, Simone
    Parris, Joshua L. D.
    Affronti, Hayley C.
    Sivanand, Sharanya
    Egolf, Shaun
    Sela, Yogev
    Trizzino, Marco
    Gardini, Alessandro
    Garcia, Benjamin A.
    Snyder, Nathaniel W.
    Stanger, Ben Z.
    Wellen, Kathryn E.
    [J]. CANCER DISCOVERY, 2019, 9 (03) : 416 - 435
  • [14] Loss of Somatostatin Receptor Subtype 2 Promotes Growth of KRAS-Induced Pancreatic Tumors in Mice by Activating PI3K Signaling and Overexpression of CXCL16
    Chalabi-Dchar, Mounira
    Cassant-Sourdy, Stephanie
    Duluc, Camille
    Fanjul, Marjorie
    Lulka, Hubert
    Samain, Remi
    Roche, Catherine
    Breibach, Florence
    Delisle, Marie-Bernadette
    Poupot, Mary
    Dufresne, Marlene
    Shimaoka, Takeshi
    Yonehara, Shin
    Mathonnet, Muriel
    Pyronnet, Stephane
    Bousquet, Corinne
    [J]. GASTROENTEROLOGY, 2015, 148 (07) : 1452 - 1465
  • [15] Incidence of pancreatic cancer is dramatically increased by a high fat, high calorie diet in KrasG12D mice
    Chang, Hui-Hua
    Moro, Aune
    Takakura, Kazuki
    Su, Hsin-Yuan
    Mo, Allen
    Nakanishi, Masako
    Waldron, Richard T.
    French, Samuel W.
    Dawson, David W.
    Hines, O. Joe
    Li, Gang
    Go, Vay Liang W.
    Sinnett-Smith, James
    Pandol, Stephen J.
    Lugea, Aurelia
    Gukovskaya, Anna S.
    Duff, Michael O.
    Rosenberg, Daniel W.
    Rozengurt, Enrique
    Eibl, Guido
    [J]. PLOS ONE, 2017, 12 (09):
  • [16] Chang XY, 2022, AM J CANCER RES, V12, P861
  • [17] Organoid model: A new hope for pancreatic cancer treatment?
    Chen, Haidi
    Zhuo, Qifeng
    Ye, Zeng
    Xu, Xiaowu
    Ji, Shunrong
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2021, 1875 (01):
  • [18] NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar-Ductal Transdifferentiation in the Pancreas
    Chen, Nai-Ming
    Singh, Garima
    Koenig, Alexander
    Liou, Geou-Yarh
    Storz, Peter
    Zhang, Jin-San
    Regul, Lisanne
    Nagarajan, Sankari
    Kuehnemuth, Benjamin
    Johnsen, Steven A.
    Hebrok, Matthias
    Siveke, Jens
    Billadeau, Daniel D.
    Ellenrieder, Volker
    Hessmann, Elisabeth
    [J]. GASTROENTEROLOGY, 2015, 148 (05) : 1024 - U502
  • [19] Cell death in pancreatic cancer: from pathogenesis to therapy
    Chen, Xin
    Zeh, Herbert J.
    Kang, Rui
    Kroemer, Guido
    Tang, Daolin
    [J]. NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2021, 18 (11) : 804 - 823
  • [20] Cell-modified plasmonic interface for the signal-amplified detection of Cucurbitacin E
    Chen, Yaofei
    Peng, Shuihua
    Zhao, Peili
    Chen, Lei
    Liu, Gui-shi
    Ouyang, Dongyun
    Luo, Yunhan
    Chen, Zhe
    [J]. BIOMEDICAL OPTICS EXPRESS, 2022, 13 (01) : 274 - 283
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