KRAS mutation: The booster of pancreatic ductal adenocarcinoma transformation and progression

被引：34

作者：

Zhang, Zining ^{[1
,2
]}

Zhang, Heng ^{[1
,2
]}

Liao, Xiang ^{[1
,2
]}

Tsai, Hsiang-i ^{[1
,2
]}

机构：

[1] Jiangsu Univ, Inst Med Imaging & Artificial Intelligence, Zhenjiang, Peoples R China

[2] Jiangsu Univ, Affiliated Hosp, Dept Med Imaging, Zhenjiang, Peoples R China

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2023年 / 11卷

基金：

中国国家自然科学基金;

关键词：

PDAC; KRAS mutation; phosphokinase; metabolic reprogramming; therapy resistance; poorer prognosis; MUTANT KRAS; GLUTAMINE-METABOLISM; MOUSE MODEL; CANCER; CELL; INHIBITOR; INITIATION; GLYCOLYSIS; KRAS(G12D); EFFICACY;

D O I：

10.3389/fcell.2023.1147676

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer. It has a poor response to conventional therapy and has an extremely poor 5-year survival rate. PDAC is driven by multiple oncogene mutations, with the highest mutation frequency being observed in KRAS. The KRAS protein, which binds to GTP, has phosphokinase activity, which further activates downstream effectors. KRAS mutation contributes to cancer cell proliferation, metabolic reprogramming, immune escape, and therapy resistance in PDAC, acting as a critical driver of the disease. Thus, KRAS mutation is positively associated with poorer prognosis in pancreatic cancer patients. This review focus on the KRAS mutation patterns in PDAC, and further emphases its role in signal transduction, metabolic reprogramming, therapy resistance and prognosis, hoping to provide KRAS target therapy strategies for PDAC.

引用

页数：16

共 160 条

[11] Pancreatic cancer cell radiation survival and prenyltransferase inhibition: The role of K-ras [J].

Brunner, TB ;

Cengel, KA ;

Hahn, SM ;

Wu, HM ;

Fraker, DL ;

McKenna, WG ;

Bernhard, EJ .

CANCER RESEARCH, 2005, 65 (18) :8433-8441

[12] Role of oncogenic KRAS in the diagnosis, prognosis and treatment of pancreatic cancer [J].

Buscail, Louis ;

Bournet, Barbara ;

Cordelier, Pierre .

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2020, 17 (03) :153-168

[13] Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis [J].

Carrer, Alessandro ;

Trefely, Sophie ;

Zhao, Steven ;

Campbell, Sydney L. ;

Norgard, Robert J. ;

Schultz, Kollin C. ;

Sidoli, Simone ;

Parris, Joshua L. D. ;

Affronti, Hayley C. ;

Sivanand, Sharanya ;

Egolf, Shaun ;

Sela, Yogev ;

Trizzino, Marco ;

Gardini, Alessandro ;

Garcia, Benjamin A. ;

Snyder, Nathaniel W. ;

Stanger, Ben Z. ;

Wellen, Kathryn E. .

CANCER DISCOVERY, 2019, 9 (03) :416-435

[14] Loss of Somatostatin Receptor Subtype 2 Promotes Growth of KRAS-Induced Pancreatic Tumors in Mice by Activating PI3K Signaling and Overexpression of CXCL16 [J].

Chalabi-Dchar, Mounira ;

Cassant-Sourdy, Stephanie ;

Duluc, Camille ;

Fanjul, Marjorie ;

Lulka, Hubert ;

Samain, Remi ;

Roche, Catherine ;

Breibach, Florence ;

Delisle, Marie-Bernadette ;

Poupot, Mary ;

Dufresne, Marlene ;

Shimaoka, Takeshi ;

Yonehara, Shin ;

Mathonnet, Muriel ;

Pyronnet, Stephane ;

Bousquet, Corinne .

GASTROENTEROLOGY, 2015, 148 (07) :1452-1465

[15] Incidence of pancreatic cancer is dramatically increased by a high fat, high calorie diet in KrasG12D mice [J].

Chang, Hui-Hua ;

Moro, Aune ;

Takakura, Kazuki ;

Su, Hsin-Yuan ;

Mo, Allen ;

Nakanishi, Masako ;

Waldron, Richard T. ;

French, Samuel W. ;

Dawson, David W. ;

Hines, O. Joe ;

Li, Gang ;

Go, Vay Liang W. ;

Sinnett-Smith, James ;

Pandol, Stephen J. ;

Lugea, Aurelia ;

Gukovskaya, Anna S. ;

Duff, Michael O. ;

Rosenberg, Daniel W. ;

Rozengurt, Enrique ;

Eibl, Guido .

PLOS ONE, 2017, 12 (09)

[16]

Chang XY, 2022, AM J CANCER RES, V12, P861

[17] Organoid model: A new hope for pancreatic cancer treatment? [J].

Chen, Haidi ;

Zhuo, Qifeng ;

Ye, Zeng ;

Xu, Xiaowu ;

Ji, Shunrong .

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2021, 1875 (01)

[18] NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar-Ductal Transdifferentiation in the Pancreas [J].

Chen, Nai-Ming ;

Singh, Garima ;

Koenig, Alexander ;

Liou, Geou-Yarh ;

Storz, Peter ;

Zhang, Jin-San ;

Regul, Lisanne ;

Nagarajan, Sankari ;

Kuehnemuth, Benjamin ;

Johnsen, Steven A. ;

Hebrok, Matthias ;

Siveke, Jens ;

Billadeau, Daniel D. ;

Ellenrieder, Volker ;

Hessmann, Elisabeth .

GASTROENTEROLOGY, 2015, 148 (05) :1024-U502

[19] Cell death in pancreatic cancer: from pathogenesis to therapy [J].

Chen, Xin ;

Zeh, Herbert J. ;

Kang, Rui ;

Kroemer, Guido ;

Tang, Daolin .

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2021, 18 (11) :804-823

[20] Cell-modified plasmonic interface for the signal-amplified detection of Cucurbitacin E [J].

Chen, Yaofei ;

Peng, Shuihua ;

Zhao, Peili ;

Chen, Lei ;

Liu, Gui-shi ;

Ouyang, Dongyun ;

Luo, Yunhan ;

Chen, Zhe .

BIOMEDICAL OPTICS EXPRESS, 2022, 13 (01) :274-283

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