DELE1 loss and dysfunctional integrated stress signaling in TP53 mutated AML is a novel pathway for venetoclax resistance

被引：0
|
作者：
Sharon, David
Jung, Paul
Sun, Yan
Feng, Weiguo
Yang, Ziping
Robinson, Valerie
Mitra, Diya
Liu, Wei
Zheng, Pingping
Uziel, Tamar
Lam, Lloyd
Minden, Mark D.
Ross, Jeremy
Mendes, Wellington
Potluri, Jalaja
Wei, Andrew H.
Konopleva, Marina
Dail, Monique
Chyla, Brenda
Epling-Burnette, P. K.
机构：
来源：
CANCER RESEARCH | 2023年 / 83卷 / 07期
关键词：
D O I：
10.1158/1538-7445.AM2023-2530
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
2530
引用
收藏
页数：3
相关论文
共 41 条
  • [1] Iron overload mediates cytarabine resistance in AML by inhibiting the TP53 signaling pathway
    Jia, Van
    Li, Ling
    Li, Ving
    Zhu, Xunxun
    Wang, Haiyan
    Xu, Bin
    Li, Qiuping
    Zhang, Hao
    ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2025, 57 (04): : 1 - 10
  • [2] DELE1 haploinsufficiency causes resistance to mitochondrial stress-induced apoptosis in monosomy 5/del(5q) AML
    Spinella, Jean-Francois
    Chagraoui, Jalila
    Moison, Celine
    Lavallee, Vincent P.
    Boivin, Isabel
    Gracias, Deanne
    Lavallee, Sylvie
    Carpentier, Guillaume Richard
    Beliveau, Francois
    Hebert, Josee
    Sauvageau, Guy
    LEUKEMIA, 2024, 38 (03) : 530 - 537
  • [3] AB1, a novel protein targeting TP53 mutated GI tumors
    Epenetos, Agamemnon A.
    Karagussova, Karima
    Deonarain, Mahendra
    JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (04)
  • [4] DELE1 haploinsufficiency causes resistance to mitochondrial stress-induced apoptosis in monosomy 5/del(5q) AML
    Jean-François Spinella
    Jalila Chagraoui
    Céline Moison
    Vincent P. Lavallée
    Isabel Boivin
    Deanne Gracias
    Sylvie Lavallée
    Guillaume Richard Carpentier
    François Beliveau
    Josée Hébert
    Guy Sauvageau
    Leukemia, 2024, 38 : 530 - 537
  • [5] ATRX LOSS IN CHINESE ADULT DIFFUSE ASTROCYTOMAS CORRELATES WITH IDH1 AND TP53 MUTATION AND PREDICTS BETTER OUTCOME IN TP53 MUTATED PATIENTS
    Chang, Qing
    Shao, Liwei
    Pan, Yi
    Qi, Xueling
    NEURO-ONCOLOGY, 2014, 16
  • [6] Capped F10, a novel DNA directed fluoropyrimidine, in TP53 mutated acute myeloid leukemia (AML)
    Pardee, Timothy S.
    Okechukwu, Charles
    Pladna, Kristin
    Gmeiner, William
    JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (16)
  • [7] Notch signaling and Tp53/RB1 pathway in pulmonary neuroendocrine tumorigenesis
    Ito, Takaaki
    Matsuo, Akira
    Hassan, Wael Abdo
    TRANSLATIONAL CANCER RESEARCH, 2016, 5 (02) : 213 - 219
  • [8] The integrated stress response (ISR) inhibitor, TR57, is synergistic with venetoclax in CLL irrespective of TP53 status
    Fatima, Narjis
    Crassini, Kyle
    Shen, Yandong
    Christopherson, Richard
    Iwanowicz, Edwin J.
    Mulligan, Stephen P.
    Best, Giles
    LEUKEMIA & LYMPHOMA, 2020, 61 : 71 - 72
  • [9] TR57, an Inhibitor of the Integrated Stress Response, Is Synergistic with Venetoclax Against CLL Cells, Independent of Their TP53 Status
    Fatima, Narjis
    Shen, Yandong
    Crassini, Kyle R.
    Iwanowicz, Edwin
    Christopherson, Richard
    Best, Giles
    Mulligan, Stephen P.
    BLOOD, 2019, 134
  • [10] Co-Targeting MCL-1 and BCL-2 Is Highly Synergistic in BH3 Mimetic- and Venetoclax/Hypomethylating AgentResistant and TP53 Mutated AML
    Carter, Bing Z.
    Mak, Po Yee
    Tao, Wenjing
    Ruvolo, Vivian
    Zhang, Xuan
    Nishida, Yuki
    Kornblau, Steven M.
    Hughes, Paul
    Chen, Xiaoyue
    Morrow, P. K.
    Andreeff, Michael
    BLOOD, 2020, 136
12345