Rh(III)-catalyzed C-H activation/intramolecular annulation for the synthesis of N-methoxydihydropyrimidin-2-one fused heterocycles

被引：1

作者：

Huang, Youchun ^{[1
]}

Kang, Ke ^{[1
]}

Zhong, Xiuwen ^{[1
]}

Yu, Yongping ^{[1
]}

Chen, Wenteng ^{[1
]}

机构：

[1] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China

来源：

TETRAHEDRON LETTERS | 2023年 / 115卷

关键词：

C -H activation; Intramolecular annulation; Rh(III)-catalyzed; N-Methoxydihydropyrimidin-2-one; CHEMODIVERGENT ANNULATIONS; REVERSE-TRANSCRIPTASE; SULFOXONIUM YLIDES; INHIBITION; ACTIVATION; INDOLES;

D O I：

10.1016/j.tetlet.2022.154311

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile rhodium-catalyzed C-H activation/intramolecular annulation strategy for N-methoxydihydropyrimidin-2-one was well realized in water media. Moreover, this Rh(III)-catalytic system facilitated the construction of N-methoxydihydropyrimidin-2-one scaffolds reminiscent of unnatural amino alcohols, transformation to pyran-2-one fused heterocycles as well as late-stage modification of drug molecules. Also, the protocol was easily scaled up to a gram-scale level. And H2O was proposed to act as an alternative coordination molecule to accelerate the generation of active Rh(III) catalyst species. (c) 2022 Elsevier Ltd. All rights reserved.

引用

页数：6

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