Nanocomposite-Based Electrochemical Sensors for Neurotransmitters Detection in Neurodegenerative Diseases

被引：16

作者：

Rajarathinam, Thenmozhi ^{[1
]}

Kang, Mijeong ^{[1
]}

Hong, Sungmoo ^{[2
]}

Chang, Seung-Cheol ^{[1
]}

机构：

[1] Pusan Natl Univ, Coll Nanosci & Nanotechnol, Dept Cogno Mechatron Engn, Pusan 46241, South Korea

[2] Pusan Natl Univ, Interdisciplinary Dept Innovat Mfg Engn, Pusan 46241, South Korea

来源：

CHEMOSENSORS | 2023年 / 11卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

neurotransmitters; neurodegenerative diseases; nanocomposite; electrochemical sensors; point-of-care diagnostics; GLASSY-CARBON ELECTRODE; SCAN CYCLIC VOLTAMMETRY; HIGH-PERFORMANCE; URIC-ACID; DOPAMINE SENSOR; PASTE ELECTRODE; ASCORBIC-ACID; SELECTIVE DETERMINATION; CONDUCTING POLYMERS; OXIDE NANOCOMPOSITE;

D O I：

10.3390/chemosensors11020103

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Neurotransmitters (NTs) are crucial regulatory molecules responsible for maintaining the neurophysiological functioning of the brain. Dysregulated levels of certain NTs, such as dopamine, serotonin, norepinephrine, epinephrine, glutamate, and gamma-aminobutyric acid, are often correlated with the pathogenesis of neurodegenerative diseases that involve the progressive and selective loss of structure or function of neuronal systems. Therefore, the identification and validation of relevant biomarkers are essential to diagnose these diseases much earlier. However, the quantitative analysis of NTs is challenging because of their dynamic release and presence of low concentrations. Accordingly, nanocomposite (NC)-based electrochemical sensors have been studied extensively and are gaining tremendous interest due to their high sensitivity, response rate, stability, portability, ease of use in point-of-care diagnostics, amenability to microprocessing, and low cost. In this review, we first briefly discuss the potential biomarkers of neurodegenerative diseases, NC-based electrochemical sensors and their advantages and disadvantages, and the properties of the NCs, which further increase the sensor performance. Finally, we summarized the future perspectives of NC-based electrochemical sensors in the clinical set-up for NTs detection to identify research gaps.

引用

页数：33

共 179 条

[1]

Ahmad HMN, 2019, 2019 20TH INTERNATIONAL CONFERENCE ON SOLID-STATE SENSORS, ACTUATORS AND MICROSYSTEMS & EUROSENSORS XXXIII (TRANSDUCERS & EUROSENSORS XXXIII), P613, DOI [10.1109/transducers.2019.8808688, 10.1109/TRANSDUCERS.2019.8808688]

[2] Non-enzymatic electrochemical sensor to detect γ-aminobutyric acid with ligand-based on graphene oxide modi fied gold electrode [J].