Hyaluronic Acid Gel Incorporating Curcumin-Phospholipid Complex Nanoparticles Prevents Postoperative Peritoneal Adhesion

被引：9

作者：

Akhlaghi, Sarah ^{[1
]}

Rabbani, Shahram ^{[2
]}

Karimi, Hanieh ^{[1
]}

Haeri, Azadeh ^{[1
,3
,4
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Sch Pharm, Dept Pharmaceut & Pharmaceut Nanotechnol, Tehran, Iran

[2] Univ Tehran Med Sci, Cardiovasc Dis Res Inst, Res Ctr Adv Technol Cardiovasc Med, Tehran, Iran

[3] Shahid Beheshti Univ Med Sci, Prot Technol Res Ctr, Tehran, Iran

[4] Shahid Beheshti Univ Med Sci, Sch Pharm, Dept Pharmaceut & Pharmaceut Nanotechnol, POB 141556153, Tehran, Iran

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 2023年 / 112卷 / 02期

关键词：

Curcumin-phospholipid complex; Hyaluronic acid; Nanoparticles; Gel; Postoperative adhesion; IMPROVING ORAL BIOAVAILABILITY; NANOFIBROUS MEMBRANES; IN-VITRO; CONTROLLED-RELEASE; DELIVERY; HYDROGEL; EFFICACY; CHITOSAN; BARRIER; DESIGN;

D O I：

10.1016/j.xphs.2022.10.022

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Peritoneal adhesions following abdominal procedures remain a major surgical issue. This study aimed to evaluate the preventive effect of curcumin-soybean phosphatidylcholine (CUR-SPC) complex-loaded nanoparticles (NPs) embedded in hyaluronic acid (HA) gel. CUR-SPC complex, CUR-SPC NPs, and CUR-SPC-HA gel were fully characterized regarding particle size, zeta potential, morphology, XRD, FTIR, in-vitro release, and rheology. The in vivo efficacy was investigated in a rat model of cecum abrasion and sidewall defect. The optimized spherical-shaped CUR-SPC NPs had a high CUR loading with nanometric particle size (93 nm). CUR-SPC-HA gel showed a pseudoplastic behavior with a homogeneous distribution of CUR-SPC NPs and a sustained release profile over 3 weeks. The inhibitory effect of CUR-SPC-NP-HA gel on fibro-blast proliferation and collagen synthesis was evidenced by histopathological (H&E and Masson trichrome staining) and immunohistochemical analyses (vimentin and collagen I expression). Thus, the proposed NP-gel hybrid system could be a promising postoperative anti-adhesion candidate, employing the advan-tages of CUR, SPC, and HA. (c) 2022 American Pharmacists Association. Published by Elsevier Inc. All rights reserved.

引用

页码：587 / 598

页数：12

共 66 条

[1] Design and Characterization of Spray-Dried Proliposomes for the Pulmonary Delivery of Curcumin [J].

Adel, Islam M. ;

ElMeligy, Mohamed F. ;

Abdelrahim, Mohamed E. A. ;

Maged, Amr ;

Abdelkhalek, AbdelFattah A. ;

Abdelmoteleb, Azza M. M. ;

Elkasabgy, Nermeen A. .

INTERNATIONAL JOURNAL OF NANOMEDICINE, 2021, 16 :2667-2687

[2] Green formulation of curcumin loaded lipid-based nanoparticles as a novel carrier for inhibition of post-angioplasty restenosis [J].

Akhlaghi, Sarah ;

Rabbani, Shahram ;

Alavi, Sonia ;

Alinaghi, Azadeh ;

Radfar, Fatemeh ;

Dadashzadeh, Simin ;

Haeri, Azadeh .

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2019, 105

[3] A new bioabsorbable polymer film to prevent peritoneal adhesions validated in a post-surgical animal model [J].

Allegre, Lucie ;

Le Teuff, Isabelle ;

Leprince, Salome ;

Warembourg, Sophie ;

Taillades, Hubert ;

Garric, Xavier ;

Letouzey, Vincent ;

Huberlant, Stephanie .

PLOS ONE, 2018, 13 (11)

[4] Intraperitoneal adhesions-An ongoing challenge between biomedical engineering and the life sciences [J].

Brochhausen, Christoph ;

Schmitt, Volker H. ;

Rajab, Taufiek K. ;

Planck, Constanze N. E. ;

Kraemer, Bernhard ;

Wallwiener, Markus ;

Hierlemann, Helmut ;

Kirkpatrick, C. James .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2011, 98A (01) :143-156

[5] Injectable thermosensitive hydrogel containing hyaluronic acid and chitosan as a barrier for prevention of postoperative peritoneal adhesion [J].

Chen, Chih-Hao ;

Chen, Shih-Hsien ;

Mao, Shih-Hsuan ;

Tsai, Ming-Jin ;

Chou, Pang-Yun ;

Liao, Chien-Hung ;

Chen, Jyh-Ping .

CARBOHYDRATE POLYMERS, 2017, 173 :721-731

[6] Dual functional core-sheath electrospun hyaluronic acid/polycaprolactone nanofibrous membranes embedded with silver nanoparticles for prevention of peritendinous adhesion [J].

Chen, Chih-Hao ;

Chen, Shih-Hsien ;

Shalumon, K. T. ;

Chen, Jyh-Ping .

ACTA BIOMATERIALIA, 2015, 26 :225-235

[7] Preparation and characterization of antiadhesion barrier film from hyaluronic acid-grafted electrospun poly(caprolactone) nanofibrous membranes for prevention of flexor tendon postoperative peritendinous adhesion [J].

Chen, Shih-Hsien ;

Chen, Chih-Hao ;

Shalumon, K. T. ;

Chen, Jyh-Ping .

INTERNATIONAL JOURNAL OF NANOMEDICINE, 2014, 9 :4079-4092

[8] The Effect of Phospholipids (Surfactant) on Adhesion and Biomechanical Properties of Tendon: A Rat Achilles Tendon Repair Model [J].

Dabak, T. Kursat ;

Sertkaya, Omer ;

Acar, Nuray ;

Donmez, B. Ozgur ;

Ustunel, Ismail .

BIOMED RESEARCH INTERNATIONAL, 2015, 2015

[9] Nanomedicine-based intraperitoneal therapy for the treatment of peritoneal carcinomatosis - Mission possible? [J].

Dakwar, George R. ;

Shariati, Molood ;

Willaert, Wouter ;

Ceelen, Wim ;

De Smedt, Stefaan C. ;

Remaut, Katrien .

ADVANCED DRUG DELIVERY REVIEWS, 2017, 108 :13-24

[10] Genipin-crosslinked gelatin microspheres as a strategy to prevent postsurgical peritoneal adhesions: In vitro and in vivo characterization [J].

De Clercq, Kaat ;

Schelfhout, Charlotte ;

Bracke, Marc ;

De Wever, Olivier ;

Van Bockstal, Mieke ;

Ceelen, Wim ;

Remon, Jean Paul ;

Vervaet, Chris .

BIOMATERIALS, 2016, 96 :33-46

← 1 2 3 4 5 6 7 →