FDG-PET/CT-guided rebiopsy may find clinically unsuspicious transformation of follicular lymphoma

被引：5

作者：

Rajamaki, Aino ^{[1
,2
]}

Kuitunen, Hanne ^{[3
]}

Sorigue, Marc ^{[4
]}

Kokkonen, Salla-Maarit ^{[5
]}

Kuittinen, Outi ^{[2
,6
,7
,8
,9
]}

Sunela, Kaisa ^{[10
]}

机构：

[1] Hosp Nova Cent Finland, Dept Oncol, Keskussairaalantie 19, Jyvaskyla 40620, Finland

[2] Univ Eastern Finland, Fac Hlth Med, Inst Clin Med, Kuopio, Finland

[3] Oulu Univ Hosp, Dept Oncol, Oulu, Finland

[4] ICO Hosp Germans Trias & Pujol, Dept Hematol, Funct Cyt IJC, Badalona, Spain

[5] Oulu Univ Hosp, Dept Nucl Med, Oulu, Finland

[6] Univ Oulu, Med Res Ctr, Oulu, Finland

[7] Univ Oulu, Canc & Translat Res Unit, Oulu, Finland

[8] Oulu Univ Hosp, Oulu, Finland

[9] Kuopio Univ Hosp, Dept Oncol, Kuopio, Finland

[10] Tampere Univ Hosp, Tays Canc Ctr, Dept Oncol, Tampere, Finland

来源：

CANCER MEDICINE | 2023年 / 12卷 / 01期

关键词：

FDG-PET/CT; follicular lymphoma; histologic transformation; indolent lymphoma; SUVmax; BASE-LINE SUVMAX; B-CELL LYMPHOMA; HISTOLOGICAL TRANSFORMATION; RITUXIMAB; RISK;

D O I：

10.1002/cam4.4924

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim: The purpose of the study was to evaluate the clinical impact of flu orodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) followed by a new biopsy from the site with maximum standardized uptake value (SUVmax) in case of high maximal SUV values, in detecting clinically unsuspected histologic transformations (HT) of follicular lymphoma (FL). Methods: This retrospective study included all the patients who had undergone FDG-PET/CT during primary diagnosis or relapse of FL between 2010 and 2020 at Oulu University Hospital. Results: The diagnosis changed from an indolent disease to a transformed lymphoma in >10% (7/63) of the patients who underwent diagnostic FDG-PET/CT. The HT risk associated with high SUVmax (>10) was 24% (7 of 29 performed biopsies). Four out of these seven patients with verified TIT had no previous clinical suspicion of transformation. Conclusion: Our results suggest that a rebiopsy based on a high SUVmax in diagnostic FDG-PET/CT is valuable in detecting clinically unsuspected HT of FL.

引用

页码：407 / 411

页数：5

共 10 条

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