FDG-PET/CT-guided rebiopsy may find clinically unsuspicious transformation of follicular lymphoma

被引：6
作者：
Rajamaki, Aino [1 ,2 ]
Kuitunen, Hanne [3 ]
Sorigue, Marc [4 ]
Kokkonen, Salla-Maarit [5 ]
Kuittinen, Outi [2 ,6 ,7 ,8 ,9 ]
Sunela, Kaisa [10 ]
机构：
[1] Hosp Nova Cent Finland, Dept Oncol, Keskussairaalantie 19, Jyvaskyla 40620, Finland
[2] Univ Eastern Finland, Fac Hlth Med, Inst Clin Med, Kuopio, Finland
[3] Oulu Univ Hosp, Dept Oncol, Oulu, Finland
[4] ICO Hosp Germans Trias & Pujol, Dept Hematol, Funct Cyt IJC, Badalona, Spain
[5] Oulu Univ Hosp, Dept Nucl Med, Oulu, Finland
[6] Univ Oulu, Med Res Ctr, Oulu, Finland
[7] Univ Oulu, Canc & Translat Res Unit, Oulu, Finland
[8] Oulu Univ Hosp, Oulu, Finland
[9] Kuopio Univ Hosp, Dept Oncol, Kuopio, Finland
[10] Tampere Univ Hosp, Tays Canc Ctr, Dept Oncol, Tampere, Finland
来源：
CANCER MEDICINE | 2023年 / 12卷 / 01期
关键词：
FDG-PET/CT; follicular lymphoma; histologic transformation; indolent lymphoma; SUVmax; BASE-LINE SUVMAX; B-CELL LYMPHOMA; HISTOLOGICAL TRANSFORMATION; RITUXIMAB; RISK;
D O I：
10.1002/cam4.4924
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim: The purpose of the study was to evaluate the clinical impact of flu orodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) followed by a new biopsy from the site with maximum standardized uptake value (SUVmax) in case of high maximal SUV values, in detecting clinically unsuspected histologic transformations (HT) of follicular lymphoma (FL). Methods: This retrospective study included all the patients who had undergone FDG-PET/CT during primary diagnosis or relapse of FL between 2010 and 2020 at Oulu University Hospital. Results: The diagnosis changed from an indolent disease to a transformed lymphoma in >10% (7/63) of the patients who underwent diagnostic FDG-PET/CT. The HT risk associated with high SUVmax (>10) was 24% (7 of 29 performed biopsies). Four out of these seven patients with verified TIT had no previous clinical suspicion of transformation. Conclusion: Our results suggest that a rebiopsy based on a high SUVmax in diagnostic FDG-PET/CT is valuable in detecting clinically unsuspected HT of FL.
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收藏
页码：407 / 411
页数：5
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