Switch of innate to adaptative immune responses in the brain of patients with Alzheimer's disease correlates with tauopathy progression

被引：2

作者：

Costa, Marcos R. ^{[1
,2
]}

机构：

[1] Univ Lille, CHU Lille, Inserm,DISTALZ, Inst Pasteur Lille,U1167 RID AGE facteurs risque &, 1 Rue Prof Calmette, F-59019 Lille, France

[2] Univ Fed Rio Grande do Norte, Brain Inst, Natal, Brazil

来源：

NPJ AGING | 2024年 / 10卷 / 01期

关键词：

INFLAMMATION;

D O I：

10.1038/s41514-024-00145-5

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Neuroinflammation is a key feature of Alzheimer's disease (AD). In this work, analysis of single- cell RNA-sequencing (scRNA-seq) data obtained from the brain of patients with AD provides evidence supporting a switch from an innate to an adaptative immune response during tauopathy progression, with both disease-associated microglia (DAM) and CD8+ T cells becoming more frequent at advanced Braak stages.

引用

页数：6

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