Structure is beauty, but not always truth

被引：17

作者：

Fraser, James S. ^{[1
]}

Murcko, Mark A. ^{[2
]}

机构：

[1] Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94158 USA

[2] Disrupt Biomed LLC, Holliston, MA 01746 USA

来源：

CELL | 2024年 / 187卷 / 03期

关键词：

D O I：

10.1016/j.cell.2024.01.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Structural biology, as powerful as it is, can be misleading. We highlight four fundamental challenges: interpreting raw experimental data; accounting for motion; addressing the misleading nature of in vitro structures; and unraveling interactions between drugs and "anti-targets."Overcoming these challenges will amplify the impact of structural biology on drug discovery.

引用

页码：517 / 520

页数：4

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