Kinin B1 receptor controls maternal adiponectin levels and influences offspring weight gain

被引：0

作者：

Alves-Silva, Thais ^{[1
,5
]}

Hungaro, Talita G. R. ^{[2
]}

Freitas-Lima, Leandro C. ^{[1
]}

Arthur, Gabriel de Melo ^{[1
]}

Arruda, Adriano C. ^{[2
]}

Santos, Raisa B. ^{[2
]}

Oyama, Lila M. ^{[3
]}

Mori, Marcelo A. S. ^{[4
]}

Bader, Michael ^{[5
,6
,7
,8
]}

Araujo, Ronaldo C. ^{[1
,2
]}

机构：

[1] Fed Univ Sao Paulo UNIFESP, Biophys Dept, Lab Genet & Exercise Metab, Mol Biol Program, BR-04039032 Sao Paulo, Brazil

[2] Fed Univ Sao Paulo UNIFESP, Biophys Dept, Nephrol Program, Lab Genet & Exercise Metab, BR-04039032 Sao Paulo, Brazil

[3] Fed Univ Sao Paulo UNIFESP, Physiol Dept, Lab Nutr & Endocrine Physiol, BR-04023901 Sao Paulo, Brazil

[4] Univ Estadual Campinas, Inst Biol, Dept Biochem & Tissue Biol, Lab Aging Biol,UNICAMP, BR-13083862 Sao Paulo, Brazil

[5] Max Delbruck Ctr Mol Med MDC, Campus Berlin Buch, D-13125 Berlin, Germany

[6] DZHK German Ctr Cardiovasc Res, Partner Site Berlin, Berlin, Germany

[7] Univ Lubeck, Inst Biol, Lubeck, Germany

[8] Charite Univ Med Berlin, Berlin, Germany

来源：

ISCIENCE | 2023年 / 26卷 / 12期

基金：

巴西圣保罗研究基金会;

关键词：

GESTATIONAL DIABETES-MELLITUS; BRADYKININ B2 RECEPTOR; PLACENTAL GLYCOGEN; B-1; RECEPTOR; TEMPOROSPATIAL CHANGES; CELL-PROLIFERATION; ADIPOSE-TISSUE; ESTROUS-CYCLE; MICE LACKING; KETONE-BODY;

D O I：

10.1016/j.isci.2023.108409

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Given the importance of the kinin B1 receptor in insulin and leptin hormonal regulation, which in turn is crucial in maternal adaptations to ensure nutrient supply to the fetus, we investigated the role of this receptor in maternal metabolism and fetoplacental development. Wild-type and kinin B1 receptor-deficient (B1KO) female mice were mated with male mice of the opposite genotype. Consequently, the entire litter was heterozygous for kinin B1 receptor, ensuring that there would be no influence of offspring genotype on the maternal phenotype. Maternal kinin B1 receptor blockade reduces adiponectin secretion by adipose tissue ex vivo , consistent with lower adiponectin levels in pregnant B1KO mice. Furthermore, fasting insulinemia also increased, which was associated with placental insulin resistance, reduced placental glycogen accumulation, and heavier offspring. Therefore, we propose the combination of chronic hyperinsulinemia and reduced adiponectin secretion in B1KO female mice create a maternal obesogenic environment that results in heavier pups.

引用

页数：19

共 86 条

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