Recent Advances in Protection-Free Glycosylations

被引：2
作者：
Li, Gefei [1 ,2 ]
Jing, Jie [1 ]
Luo, Zhenyang [1 ]
Mo, Juan [2 ]
Xiong, Decai [2 ]
Ye, Xinshan [2 ]
机构：
[1] Nanjing Forestry Univ, Sch Sci, Nanjing 210037, Peoples R China
[2] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
来源：
CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 43卷 / 06期
基金：
中国国家自然科学基金;
关键词：
chemical glycosylation; protection-free; direct anomeric activation; carbohydrate chemistry; UNPROTECTED SUGARS; ALKYL GLYCOSIDES; P-TOLUENESULFONOHYDRAZIDE; ACID; ACTIVATION; CHEMISTRY; CATALYSIS; MILD;
D O I：
10.6023/cjoc202211024
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Carbohydrates play a key role in many life activities, such as cell wall composition, energy storage and biological recognition. Development of highly regio- and stereo-selective glycosylation reactions is a central topic of current carbohydrate chemistry. The traditional glycosylation protocol usually requires the orthogonal protecting chemistry to obtain the selectivity of glycosylation reactions. Recent progress in protecting-group free strategies can provide a simple and mild approach to the chemo-selective construction of glycosidic bonds in oligosaccharides or glycoconjugates in aqueous conditions. The latest advances in protection-free chemical glycosylations are summarized, including the direct anomeric activation strategy developed by our group.
引用
收藏
页码：1991 / 2001
页数：11
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