Pan-cancer analyses reveal multi-omic signatures and clinical implementations of the forkhead-box gene family

被引：3

作者：

Bi, Xiaoman ^{[1
]}

Zheng, Dehua ^{[1
]}

Cai, Jiale ^{[1
]}

Xu, Dahua ^{[1
]}

Chen, Liyang ^{[1
]}

Xu, Zhizhou ^{[1
]}

Cao, Meng ^{[1
]}

Li, Peihu ^{[1
]}

Shen, Yutong ^{[1
]}

Wang, Hong ^{[1
]}

Zheng, Wuping ^{[2
]}

Wu, Deng ^{[3
]}

Zheng, Shaojiang ^{[1
,4
]}

Li, Kongning ^{[1
]}

机构：

[1] Hainan Med Univ, Canc Inst, Coll Biomed Informat & Engn, Key Lab Trop Translat Med,Minist Educ,Affiliated H, Haikou, Peoples R China

[2] Hainan Med Univ, Affiliated Hosp 2, Dept Breast Thorac Tumor, Haikou, Peoples R China

[3] Chinese Univ Hong Kong, Fac Sci, Sch Life Sci, Hong Kong, Peoples R China

[4] Hainan Med Univ, Hainan Women & Childrens Med Ctr, Key Lab Emergency & Trauma, Key Lab Trop Cardiovasc Dis Res Hainan Prov,Minist, Haikou, Peoples R China

来源：

CANCER MEDICINE | 2023年 / 12卷 / 16期

基金：

海南省自然科学基金; 中国国家自然科学基金;

关键词：

database; Forkhead box; multi-omics; pan-cancer; transcription factor; BREAST-CANCER; TRANSCRIPTION FACTORS; DRUG-SENSITIVITY; FOXA1; CELLS; EXPRESSION; ROLES; PROLIFERATION; INHIBITION; APOPTOSIS;

D O I：

10.1002/cam4.6312

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Forkhead box (FOX) proteins belong to one of the largest transcription factor families and play crucial roles in the initiation and progression of cancer. Prior research has linked several FOX genes, such as FOXA1 and FOXM1, to the crucial process of carcinogenesis. However, the overall picture of FOX gene family across human cancers is far from clear.Methods: To investigate the broad molecular signatures of the FOX gene family, we conducted study on multi-omics data (including genomics, epigenomics and transcriptomics) from over 11,000 patients with 33 different types of human cancers.Results: Pan-cancer analysis reveals that FOX gene mutations were found in 17.4% of tumor patients with a substantial cancer type-dependent pattern. Additionally, high expression heterogeneity of FOX genes across cancer types was discovered, which can be partially attributed to the genomic or epigenomic alteration. Co-expression network analysis reveals that FOX genes may exert functions by regulating the expression of both their own and target genes. For a clinical standpoint, we provided 103 FOX gene-drug target-drug predictions and found FOX gene expression have potential survival predictive value. All of the results have been included in the FOX2Cancer database, which is freely accessible at http://hainmu-biobigdata.com/FOX2Cancer.Conclusion: Our findings may provide a better understanding of roles FOX genes played in the development of tumors, and help to offer new avenues for uncovering tumorigenesis and unprecedented therapeutic targets.

引用

页码：17428 / 17444

页数：17

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