Primary Central Nervous System Vasculitis Following Alemtuzumab Treatment for Multiple Sclerosis A Case Report and Literature Review

被引：1

作者：

Varela, Lucia ^{[1
]}

Pappolla, Agustin ^{[3
]}

Heriz, Alejandra ^{[1
]}

Marquez, Rocio ^{[1
]}

Vega, Otto ^{[1
]}

Christiansen, Silvia ^{[2
]}

Rugiero, Marcelo ^{[1
]}

Midaglia, Luciana ^{[3
]}

Salerno, Annalaura ^{[4
,5
]}

Tintore, Mar ^{[3
]}

Rovira, Alex ^{[4
,5
]}

机构：

[1] Italian Hosp Buenos Aires, Dept Neurol, Buenos Aires, DF, Argentina

[2] Italian Hosp Buenos Aires, Dept Pathol, Buenos Aires, DF, Argentina

[3] Vall dHebron Barcelona Hosp Campus, Multiple Sclerosis Ctr Catalonia Cemcat, Barcelona 08035, Spain

[4] Univ Autonoma Barcelona, Hosp Univ Vall dHebron, Sect Neuroradiol, Dept Radiol IDI,Vall dHebron Inst Recerca, Barcelona, Spain

[5] Univ Autonoma Barcelona, Hosp Univ Vall dHebron, Magnet Resonance Unit, Dept Radiol IDI,Vall dHebron Inst Recerca, Barcelona, Spain

来源：

NEUROLOGIST | 2023年 / 28卷 / 04期

关键词：

alemtuzumab; multiple sclerosis; seizure; central nervous system vasculitis; encephalitis;

D O I：

10.1097/NRL.0000000000000480

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction:Cerebral vasculitides are often devastating conditions that require immediate diagnosis and treatment. Case report:We report a pathologically proven clinical case of primary central nervous system vasculitis in a 50-year-old man with a diagnosis of relapsing-remitting multiple sclerosis after alemtuzumab therapy, which required additional immunosuppression to control this life-threatening condition. Conclusion:In patients presenting subacute neurological deterioration after alemtuzumab therapy, primary central nervous system vasculitis should be considered as a differential diagnosis among other autoimmune conditions.

引用

页码：270 / 272

页数：3

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