Primary Central Nervous System Vasculitis Following Alemtuzumab Treatment for Multiple Sclerosis A Case Report and Literature Review

被引：1

作者：

Varela, Lucia ^{[1
]}

Pappolla, Agustin ^{[3
]}

Heriz, Alejandra ^{[1
]}

Marquez, Rocio ^{[1
]}

Vega, Otto ^{[1
]}

Christiansen, Silvia ^{[2
]}

Rugiero, Marcelo ^{[1
]}

Midaglia, Luciana ^{[3
]}

Salerno, Annalaura ^{[4
,5
]}

Tintore, Mar ^{[3
]}

Rovira, Alex ^{[4
,5
]}

机构：

[1] Italian Hosp Buenos Aires, Dept Neurol, Buenos Aires, DF, Argentina

[2] Italian Hosp Buenos Aires, Dept Pathol, Buenos Aires, DF, Argentina

[3] Vall dHebron Barcelona Hosp Campus, Multiple Sclerosis Ctr Catalonia Cemcat, Barcelona 08035, Spain

[4] Univ Autonoma Barcelona, Hosp Univ Vall dHebron, Sect Neuroradiol, Dept Radiol IDI,Vall dHebron Inst Recerca, Barcelona, Spain

[5] Univ Autonoma Barcelona, Hosp Univ Vall dHebron, Magnet Resonance Unit, Dept Radiol IDI,Vall dHebron Inst Recerca, Barcelona, Spain

来源：

NEUROLOGIST | 2023年 / 28卷 / 04期

关键词：

alemtuzumab; multiple sclerosis; seizure; central nervous system vasculitis; encephalitis;

D O I：

10.1097/NRL.0000000000000480

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction:Cerebral vasculitides are often devastating conditions that require immediate diagnosis and treatment. Case report:We report a pathologically proven clinical case of primary central nervous system vasculitis in a 50-year-old man with a diagnosis of relapsing-remitting multiple sclerosis after alemtuzumab therapy, which required additional immunosuppression to control this life-threatening condition. Conclusion:In patients presenting subacute neurological deterioration after alemtuzumab therapy, primary central nervous system vasculitis should be considered as a differential diagnosis among other autoimmune conditions.

引用

页码：270 / 272

页数：3

共 50 条

[1] Early neutropenia with thrombocytopenia following alemtuzumab treatment for multiple sclerosis: case report and review of literature
Maniscalco, G. T.
Cerillo, I.
Servillo, G.
Napolitano, M.
Guarcello, G.
Abate, V.
Improta, G.
Florio, C.
CLINICAL NEUROLOGY AND NEUROSURGERY, 2018, 175 : 134 - 136
[2] Hemophagocytic syndrome following alemtuzumab treatment for multiple sclerosis: A case report
Romero, A.
Midaglia, L.
Salcedo, M. T.
Viladomiu, L.
Guillen, E.
Bajana, I
Escola-Verge, L.
Tintore, M.
Montalban, X.
Len, O.
MULTIPLE SCLEROSIS AND RELATED DISORDERS, 2020, 40
[3] Primary angiitis of the central nervous system as a mimic of multiple sclerosis: A case report
Tieppo, Eduardo Macedo de Souza
da Silva, Tomas Fraga Ferreira
Araujo, Roger Santana
Silva, Guilherme Diogo
Paes, Vitor Ribeiro
Rimkus, Carolina de Medeiros
Tinone, Gisela
Pereira, Samira Apostolos
Callegaro, Dagoberto
JOURNAL OF NEUROIMMUNOLOGY, 2022, 373
[4] Alopecia Universalis following Alemtuzumab Treatment in Multiple Sclerosis: A Barely Recognized Manifestation of Secondary Autoimmunity-Report of a Case and Review of the Literature
Zimmermann, Julian
Buhl, Timo
Mueller, Marcus
FRONTIERS IN NEUROLOGY, 2017, 8
[5] Alemtuzumab-related eosinophilic central nervous system vasculitis
Leach, Oliver A.
Hilton, David A.
Adams, William
Love, Seth
Straukiene, Agne
MULTIPLE SCLEROSIS JOURNAL, 2020, 26 (12) : 1602 - 1606
[6] Primary Central Nervous System Vasculitis Mimicking Susac Syndrome and Multiple Sclerosis With Long-Term Remission and Spontaneous Resolution of Lesions: A Case Report
Koseki, Akihito
Suzuki, Youji
Uchida, Shugo
Morishita, Naoki
Hokazono, Yukio
Kuriki, Ken
Yamamura, Yasuhiro
Yoshida, Mari
Sakai, Naoki
CUREUS JOURNAL OF MEDICAL SCIENCE, 2024, 16 (07)
[7] Alemtuzumab as rescue therapy in case of multiple sclerosis rebound following Natalizumab break: Clinical case and literature review
Federle, Lisa
Puthenparampil, Marco
Stenta, Gianola
Paolo, Gallo
Francesco, Perini
MULTIPLE SCLEROSIS AND RELATED DISORDERS, 2019, 30 : 262 - 264
[8] Sarcoidosis following alemtuzumab treatment for multiple sclerosis
Willis, Mark D.
Hope-Gill, Ben
Flood-Page, Patrick
Joseph, Fady
Needham, Ed
Jones, Joanne
Coles, Alasdair
Robertson, Neil P.
MULTIPLE SCLEROSIS JOURNAL, 2018, 24 (13) : 1779 - 1782
[9] Melanoma following treatment with alemtuzumab for multiple sclerosis
Pace, A. A.
Zajicek, J. P.
EUROPEAN JOURNAL OF NEUROLOGY, 2009, 16 (04) : E70 - E71
[10] Central nervous system vasculitis in a patient with axial spondyloarthritis treated with infliximab: A case report and literature review
Panagopoulos, Panagiotis
Katsifis, Gkikas
EUROPEAN JOURNAL OF RHEUMATOLOGY, 2021, 8 (04) : 228 - 231

← 1 2 3 4 5 →