A flexible carbon nanofiber and conjugated polymer-based electrode for glucose sensing

被引:13
作者
Bulut, Umut [1 ]
Sayin, Vuslat Oyku [1 ]
Altin, Yasin [2 ]
Cevher, Sevki Can [3 ]
Cirpan, Ali [4 ,5 ,6 ,7 ]
Bedeloglu, Ayse Celik [2 ]
Soylemez, Saniye [8 ]
机构
[1] Acibadem Mehmet Ali Aydinlar Univ, Dept Analyt Chem, Fac Pharm, Istanbul, Turkiye
[2] Bursa Tech Univ, Dept Polymer Mat Engn, Bursa, Turkiye
[3] Sivas Univ Sci & Technol, Dept Engn Fundamental Sci, Sivas, Turkiye
[4] Middle East Tech Univ, Dept Chem, Fac Sci, Ankara, Turkiye
[5] Middle East Tech Univ, Dept Polymer Sci & Technol, TR-06800 Ankara, Turkiye
[6] Middle East Tech Univ, Ctr Solar Energy Res & Applicat GUNAM, Ankara, Turkiye
[7] Middle East Tech Univ, Dept Micro & Nanotechnol, TR-06800 Ankara, Turkiye
[8] Necmettin Erbakan Univ, Dept Biomed Engn, Fac Engn, Konya, Turkiye
关键词
Glucose detection; Carbon nanofiber; Conjugated random polymer; Enzyme immobilization; Glucose oxidase; CONDUCTING POLYMER; SIDE-CHAINS; PERFORMANCE; NANOTUBES; NANOTECHNOLOGY; STABILIZATION; TRANSISTORS; REDUCTION; BIOSENSOR; PLATFORM;
D O I
10.1016/j.microc.2022.108148
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Herein, a specific and stable biosensor for glucose using a flexible, modified electrode with a carbon nanofiber (CNF) and a novel conjugated polymer including three moieties of benzotriazole, benzodithiophene, and benzenediamine (P-BDT-BTz:BDA) as a platform was designed. For this purpose, polyacrylonitrile (PAN) nanofiber mats were obtained by a solution-based electrospinning method. PAN nanofiber mats were stabilized and carbonized to turn into carbon nanofibers and the sensing platform was formed by combining the nanofibers on a defined area of a flexible polyethylene terephthalate (PET) substrate. In addition, a random conjugated polymer, P-BDT-BTz:BDA, was synthesized, characterized, and used as a modifier of a CNF-coated transducer surface for glucose detection. The effect of each parameter on biosensor response was evaluated. Under optimized conditions, the electrode responded to glucose in a linear concentration range of 20 mu M to 500 mu M with a detection limit of 8.5 mu M. In addition, it was observed that the designed biosensor has a good sensing ability for glucose in beverages. The results of our study show that the proposed amperometric glucose oxidase (GOx)-based biosensor has high specificity, a low limit of detection, and an extended range of linear detection for glucose.
引用
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页数:10
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