Iridium-Catalyzed Site- and Enantioselective C(sp2)-H Borylation of Benzhydryl Ethers: Enantioselectivity Amplification by Kinetic Resolution Relay

被引：7
|
作者：
Jing, Ke [1 ,2 ]
Chen, Lili [1 ]
Zhang, Panke [2 ]
Xu, Senmiao [1 ]
机构：
[1] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Gansu, Peoples R China
[2] Zhengzhou Univ, Coll Chem, Green Catalysis Ctr, Zhengzhou 450001, Henan, Peoples R China
来源：
CHINESE JOURNAL OF CHEMISTRY | 2023年 / 41卷 / 17期
基金：
中国国家自然科学基金;
关键词：
Asymmetric catalysis; Benzhydryl ethers; C-H activation; Enantioselectivity; Kinetic resolution; C-H OLEFINATION; ACTIVATION; IODINATION; ARENES; BONDS; ACIDS;
D O I：
10.1002/cjoc.202300161
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Comprehensive SummaryWe herein report a simple ether-directed iridium-catalyzed site- and enantioselective C(sp(2))-H borylation of benzhydryl ethers for the first time. Various chiral benzhydryl ethers were obtained with high enantioselectivities in the presence of a tailor-made chiral bidentate boryl ligand. We found that the kinetic resolution relay significantly amplified the enantioselectivity. The synthetic utility of the current method was demonstrated by gram-scale C-H borylation and C-B bond transformations.
引用
收藏
页码：2119 / 2124
页数：6
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