Biodegradable organosilica-based targeted and redox-responsive delivery system of resveratrol for efficiently alleviating ulcerative colitis

被引：7

作者：

Jiang, Dan ^{[1
,2
]}

Xia, Xiaoyang ^{[2
]}

He, Zhixiong ^{[1
,2
]}

Xue, Yanan ^{[1
]}

Xiang, Xia ^{[2
]}

机构：

[1] Wuhan Inst Technol, Hubei Engn Res Ctr Adv Fine Chem, Sch Chem Engn & Pharm,Minist Educ, Hubei Key Lab Novel Reactor & Green Chem Technol,K, Wuhan 430205, Peoples R China

[2] Chinese Acad Agr Sci, Oil Crops Res Inst, Oil Crops & Lipids Proc Technol Natl & Local Joint, Key Lab Oilseeds Proc,Minist Agr & Rural Affairs,H, Wuhan 430062, Peoples R China

来源：

JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | 2023年 / 123卷

基金：

中国国家自然科学基金;

关键词：

Organosilica; Resveratrol; Chondroitin sulfate; Redox-responsive release; Ulcerative colitis; MESOPOROUS SILICA NANOPARTICLES; OXIDATIVE STRESS;

D O I：

10.1016/j.jiec.2023.03.055

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Ulcerative colitis (UC) is characterized by a low redox potential in the colon. Targeting redox-responsive strategies are highly desirable due to the capacity of improving the treatment efficiency of drugs against UC. Resveratrol (Res), a natural ingredient, possesses prominent anti-inflammatory activity. However, the limited bioavailability and poor water-solubility severely hinder its clinical translation. Herein, we fabricate an oral delivery carrier of Res-encapsulated tetrasulfide-containing organosilica nanoparticles (DSMSNs), functionalized by targeting component chondroitin sulfate (CS). Benefiting from smart "switch" and targeted "guider", CS shell enables high internalization and promotes selective accumulation in colon epithelial cells and macrophages through CD44-mediated pathway; meanwhile, glutathione (GSH) response-mediated rapid disassembly exhibits targeted Res release and efficient biodegradation, consequently achieving enhanced intracellular delivery of Res, improved Res-enabled treatment and recovered gut microbial diversity in the colitis model to mitigate colonic inflammation. These findings thus bring fresh insights into the potential of MONs in UC treatment as an oral delivery platform. (c) 2023 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.

引用

页码：382 / 395

页数：14

共 45 条

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