Water treatment using RO is one of the most cost-effective methods. This study investigates how temperature affects pressure drop and NDP in SWRO and BWRO units. For each membrane used in hybrid and simple single-stage configurations of the RO systems, the results showed a reduction in pressure drop and NDP at higher temperatures. Based on the simulations performed, the average pressure drop and NDP of the hybrid single-stage configuration were less than the simple single-stage design of the BWRO system. Besides, the NDP in the hybrid single-stage configuration was lower than in the simple single-stage configuration, and the value of NDP in the two configurations differed by 0.32 bar. Each membrane induced a lower pressure drop at higher temperatures and required less driving pressure. As a result, the total pressure drop of hybrid and simple two-stage configurations was lower at higher temperatures. The average driving pressure of the hybrid two-stage configuration was less than the simple two-stage configuration, and the average driving pressure differed by a minimum of 0.11 bar. At higher temperatures, each membrane induced lower pressure drops in two-stage configurations. Also, a reduction of the driving pressure in each membrane in the SWRO system was observed. According to observations, the simple single-stage configuration of the SWRO system induced higher pressure drops than the hybrid single-stage configuration. Also, the total average driving pressure in the hybrid single-stage configuration was more significant than in the simple single-stage configuration, and the two differed by 0.18 bar. However, the hybrid single-stage configuration experienced smaller total pressure drops than the simple single-stage configuration, and the two differed by a minimum of 0.06 bar. The results of this paper can be used to improve and optimize the design of RO systems based on operating temperatures.