Retinal organoids from human-induced pluripotent stem cells: From studying retinal dystrophies to early diagnosis of Alzheimer?s and Parkinson?s disease

被引:13
作者
Movio, Marilia Ines [1 ]
de Lima-Vasconcellos, Theo Henrique [1 ]
dos Santos, Gabrieli Bovi [1 ]
Echeverry, Marcela Bermudez [2 ]
Colombo, Elisabetta [3 ,4 ]
Mattos, Leonardo S. [5 ]
Resende, Rodrigo Ribeiro [6 ]
Kihara, Alexandre Hiroaki [1 ,2 ]
机构
[1] Univ Fed ABC, Lab Neurogenet, Sao Bernardo Do Campo, SP, Brazil
[2] Univ Fed ABC, Ctr Matemat Comp & Cognicao, Sao Bernardo Do Campo, SP, Brazil
[3] Ist Italiano Tecnol, Ctr Synapt Neurosci & Technol, Genoa, Italy
[4] IRCCS Osped Policlin San Martino, Genoa, Italy
[5] Ist Italiano Tecnol, Dept Adv Robot, Biomed Robot Lab, Genoa, Italy
[6] Univ Fed Minas Gerais, Dept Biochem & Immunol, Belo Horizonte, MG, Brazil
基金
巴西圣保罗研究基金会;
关键词
Transcriptome; Retinitis pigmentosa; Single-cell analyses; HiPSC; Cell therapy; Retina; Retinal diseases; RETINITIS-PIGMENTOSA; EXPRESSION; MICROGLIA; MODEL; PHOTORECEPTORS; EPITHELIUM; MECHANISM; PATHOLOGY; PROTEIN; GENE;
D O I
10.1016/j.semcdb.2022.09.011
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Human-induced pluripotent stem cells (hiPSCs) have provided new methods to study neurodegenerative dis-eases. In addition to their wide application in neuronal disorders, hiPSCs technology can also encompass specific conditions, such as inherited retinal dystrophies. The possibility of evaluating alterations related to retinal disorders in 3D organoids increases the truthfulness of in vitro models. Moreover, both Alzheimer's (AD) and Parkinson's disease (PD) have been described as causing early retinal alterations, generating beta-amyloid protein accumulation, or affecting dopaminergic amacrine cells. This review addresses recent advances and future perspectives obtained from in vitro modeling of retinal diseases, focusing on retinitis pigmentosa (RP). Additionally, we depicted the possibility of evaluating changes related to AD and PD in retinal organoids ob-tained from potential patients long before the onset of the disease, constituting a valuable tool in early diagnosis. With this, we pointed out prospects in the study of retinal dystrophies and early diagnosis of AD and PD.
引用
收藏
页码:77 / 86
页数:10
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