A clash of quorum sensing vs quorum sensing inhibitors: an overview and risk of resistance

被引：19
作者：
Patel, Rohit [1 ]
Soni, Mansi [1 ]
Soyantar, Bilv [1 ]
Shivangi, Suruchi [1 ]
Sutariya, Swati [1 ]
Saraf, Meenu [1 ]
Goswami, Dweipayan [1 ]
机构：
[1] Gujarat Univ, Univ Sch Sci, Dept Microbiol & Biotechnol, Ahmadabad 380009, Gujarat, India
来源：
ARCHIVES OF MICROBIOLOGY | 2023年 / 205卷 / 04期
关键词：
Quorum sensing; Biofilm; Quorum quenching; Quorum quenching compounds; Quorum sensing inhibition; Quorum sensing resistance; TO-CELL COMMUNICATION; STAPHYLOCOCCUS-AUREUS BIOFILMS; HOMOSERINE LACTONE ACYLASE; MULTIDRUG EFFLUX SYSTEM; PHENOL-SOLUBLE MODULINS; VIRULENCE FACTORS; CANDIDA-ALBICANS; ESCHERICHIA-COLI; REGULATORY COMPONENTS; HALOGENATED FURANONES;
D O I：
10.1007/s00203-023-03442-x
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Indiscriminate use of antibiotics to treat microbial pathogens has caused emergence of multiple drug resistant strains. Most infectious diseases are caused by microbes that are capable of intercommunication using signaling molecules, which is known as quorum sensing (QS). Such pathogens express their pathogenicity through various QS-regulated virulence factors. Interference of QS could lead to decisive results in controlling such pathogenicity. Hence, QS inhibition has become an attractive new approach for the development of novel drugs. Many quorum sensing inhibitors (QSIs) of diverse origins have been reported. It is imperative that more such anti-QS compounds be found and studied, as they have significant effect on microbial pathogenicity. This review attempts to give a brief account of QS mechanism, its inhibition and describes some compounds with anti-QS potential. Also discussed is the possibility of emergence of quorum sensing resistance.
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页数：23
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