Altered structural and functional homotopic connectivity associated with the progression from mild cognitive impairment to Alzheimer's disease

被引：16
作者：
Chen, Shanshan [1 ]
Wu, Huimin [1 ]
Song, Yu [1 ]
Ge, Honglin [2 ]
Yan, Zheng [2 ]
Xue, Chen [3 ]
Qi, Wenzhang [3 ]
Yuan, Qianian [3 ]
Lin, Xingjian [1 ]
Chen, Jiu [4 ]
机构：
[1] Nanjing Med Univ, Affiliated Brain Hosp, Dept Neurol, Nanjing 210029, Jiangsu, Peoples R China
[2] Nanjing Med Univ, Affiliated Brain Hosp, Inst Brain Funct Imaging, Nanjing 210029, Jiangsu, Peoples R China
[3] Nanjing Med Univ, Affiliated Brain Hosp, Dept Radiol, Nanjing 210029, Jiangsu, Peoples R China
[4] Nanjing Univ, Med Sch, Affiliated Drum Tower Hosp, Dept Radiol, Nanjing 210008, Peoples R China
来源：
PSYCHIATRY RESEARCH | 2023年 / 319卷
基金：
中国国家自然科学基金; 美国国家卫生研究院;
关键词：
Alzheimer?s disease; Progressive mild cognitive impairment; Stable mild cognitive impairment; Voxel-mirrored homotopic connectivity; CORPUS-CALLOSUM; MEMORY; NETWORK; DECLINE; ATROPHY; EEG; ORGANIZATION; ASYMMETRY; THALAMUS; AGENESIS;
D O I：
10.1016/j.psychres.2022.115000
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
The progressive mild cognitive impairment (pMCI) is associated with an increased risk of Alzheimer's disease (AD). Many studies have reported the disrupted brain alteration during the imminent conversion from pMCI to AD. However, the subtle difference of structural and functional of inter-hemispheric between pMCI and stable mild cognitive impairment (sMCI) remains unknown. In the present study, we scanned the multimodal magnetic resonance imaging of 38 sMCI, 26 pMCI, and 50 healthy controls (HC) and assessed the cognitive function. The voxel-mirrored homotopic connectivity (VMHC) and volume of corpus callosum were calculated. A structural equation modeling (SEM) was established to determine the relationships between the corpus callosum, the inter-hemispheric connectivity, and cognitive assessment. Compared to sMCI, pMCI exhibited decreased VMHC in insular and thalamus, and reduced volume of corpus callosum. SEM results showed that decreased inter-hemispheric connectivity was directly associated with cognitive impairment and corpus callosum atrophy, and corpus callosum atrophy indirectly caused cognitive impairment by mediating inter-hemispheric connectivity in pMCI. In conclusion, the destruction of homotopic connectivity is related to cognitive impairment, and the corpus callosum atrophy partially mediates the association between the homotopic connectivity and cognitive impairment in pMCI.
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页数：10
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