A cohort analysis of patients receiving neoadjuvant androgen deprivation therapy prior to robot-assisted laparoscopic prostatectomy during the Covid-19 pandemic

被引:1
|
作者
Bennett, Sahan S. [1 ]
Leung, Hing Y. [2 ,3 ]
Ahmad, Imran [2 ,3 ]
机构
[1] Univ Glasgow, Coll Med Vet & Life Sci, Glasgow G2 8QQ, Lanark, Scotland
[2] Beatson Inst Canc Res, Garscube Estate,Switchback Rd, Glasgow G61 1BD, Lanark, Scotland
[3] Univ Glasgow, Inst Canc Sci, Glasgow, Lanark, Scotland
关键词
Prostate cancer; localised; neoadjuvant; androgen deprivation therapy; Covid-19; RADICAL PROSTATECTOMY; CANCER;
D O I
10.1177/20514158211022216
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Objectives: The purpose of this study was to investigate localised prostate cancer treated with or without neoadjuvant androgen deprivation therapy prior to robot-assisted laparoscopic prostatectomy, and the impact of Covid-19 treatment disruption, on clinico-pathologic outcomes. Patients and methods: Data was retrospectively collected from 124 consecutive patients treated with robot-assisted laparoscopic prostatectomy between November 2019-September 2020. Sixty-two patients were treated before 13 March 2020 (historic cohort) and 62 afterwards (covid cohort). Thirty-seven patients in the covid cohort additionally received neoadjuvant androgen deprivation therapy (mean duration of 3 months) consisting of bicalutamide 150 mg once a day for 4 weeks, with leuprolide 3.75 mg monthly injections commencing after week 1, up until the date of surgery. Results: Statistical analysis found no difference in peri-operative measures and length of stay for patients treated with or without neoadjuvant androgen deprivation therapy. Patients with delayed surgical treatment offered neoadjuvant androgen deprivation therapy showed a trend towards a reduction in positive surgical margins (p=0.134), N1 disease (p=0.424) and pathological down-staging (50% patients with pT2 disease). Patients within the covid cohort experienced significantly increased detectable prostate-specific antigen levels (p<0.007). Conclusion: Our study demonstrated that a three-month duration of neoadjuvant androgen deprivation therapy prior to robot-assisted laparoscopic prostatectomy may improve pathological outcomes but this time-frame is inadequate to influence detectable prostate-specific antigen levels. Covid-19-related treatment delays led to significantly increased detectable prostate-specific antigen levels.
引用
收藏
页码:131 / 139
页数:9
相关论文
共 50 条
  • [31] ASSISTED REPRODUCTIVE TECHNOLOGY PROCEDURES IN THE US PRIOR TO AND DURING THE COVID-19 PANDEMIC.
    Chae-Kim, Jennifer
    Kim, Tongil T. I.
    Gavrilova-Jordan, Larisa
    Bates, Gordon Wright
    FERTILITY AND STERILITY, 2021, 116 (03) : E299 - E299
  • [32] Androgen deprivation therapy improves pneumoperitoneum time during laparoscopic radical prostatectomy in Japanese patients with enlarged prostates
    Takeda, Toshikazu
    Miyajima, Akira
    Kaneko, Gou
    Kikuchi, Eiji
    Nakagawa, Ken
    Oya, Mototsugu
    ASIAN JOURNAL OF ENDOSCOPIC SURGERY, 2014, 7 (02) : 145 - 151
  • [33] A novel technique for ureteral stent placement prior to bladder neck reconstruction during robot-assisted laparoscopic radical prostatectomy (RALRP)
    Gaitonde, K.
    Giesler, E. J.
    Bracken, R. B.
    Donovan, J. F.
    JOURNAL OF ENDOUROLOGY, 2006, 20 : A275 - A275
  • [34] Disparities in pediatric patients receiving proton therapy during the COVID-19 pandemic - A single institutional experience
    McKinnon, Samuel P.
    Kazmierczak, Zara I.
    Olch, Arthur J.
    Roh, Daniel
    Nguyen, Ethan
    Pang, Kristen
    MacEwan, Iain J.
    Wong, Kenneth K.
    CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2023, 32 (01) : 182 - 183
  • [35] A Comparative Study of Profile of Patients Receiving Electroconvulsive Therapy During the COVID-19 Pandemic and a Year Before
    Grover, Sandeep
    Rani, Seema
    Chakrabarti, Subho
    Mehra, Aseem
    Sahoo, Swapnajeet
    Panda, Nidhi
    JOURNAL OF ECT, 2021, 37 (04) : E41 - E42
  • [36] Relative Timing of Radiotherapy and Androgen Deprivation for Prostate Cancer and Implications for Treatment During the COVID-19 Pandemic
    Dee, Edward Christopher
    Mahal, Brandon A.
    Arega, Melaku A.
    D'Amico, Anthony V.
    Mouw, Kent W.
    Nguyen, Paul L.
    Muralidhar, Vinayak
    JAMA ONCOLOGY, 2020, 6 (10) : 1630 - 1632
  • [37] Letter to the Editor: Robot-Assisted and Minimally Invasive Pediatric Surgery and Urology During the COVID-19 Pandemic: A Short Literature Review
    Esposito, Ciro
    Masieri, Lorenzo
    Castagnetti, Marco
    Crocetto, Felice
    Escolino, Maria
    JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES, 2020, 30 (08): : 915 - 918
  • [38] Safety of uro-oncology practice and robot-assisted surgery during the peak of COVID-19 pandemic: A report from India
    Dev, Preetham
    Yuvaraja, T. B.
    Waigankar, Santosh S.
    Ranade, Sharmila
    Pednekar, Abhinav P.
    Agarwal, Varun
    Khandekar, Archan
    Badlani, Naresh
    Asari, Ashish
    JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, 2022, 18 (06) : 1629 - 1634
  • [39] Effects of Androgen Deprivation Therapy on COVID-19 in Patients with Prostate Cancer: A Systematic Review and Meta-Analysis
    Karimi, Amirali
    Nowroozi, Ali
    Alilou, Sanam
    Amini, Erfan
    UROLOGY JOURNAL, 2021, 18 (06) : 577 - 584
  • [40] Patients with appendicitis during COVID-19 pandemic: a retrospective cohort study
    Ricard, Elizabeth
    Marceau, Alexandre
    Larouche, Gabrielle
    Dorval, Heidi
    Malo, Francois-Charles
    ANNALS OF MEDICINE AND SURGERY, 2023, 85 (05): : 1507 - 1512