Risk factors in developing retinal vein occlusion in subject with obstructive sleep apnea

BACKGROUND: Patients with obstructive sleep apnea (OSA) have a higher risk of developing vascular diseases. In this study, we evaluated the clinical profile of patients with OSA who develop retinal vein occlusion (RVO) compared with a population of OSA patients without RVO. METHODS: We analyzed patients with OSA diagnosed with RVO (21 cases; mean of age 61 years. range 44-87 years. 67% men), belonging to a large cohort of people with long-term follow-up for RVO (up to 12 years). We compared them with 21 patients with OSA, without RVO, matched by age and gender, selected from the Sleep Unit Registry (control group). RESULTS: There were no differences in the prevalence of arterial hypertension (AHT) or Diabetes mellitus (DM), but the RVO patients presented a higher diastolic blood pressure compared to controls (87.6 +/- 12.6 mmHg vs. 77.9 +/- 10.1 mmHg respectively). The polygraphic parameters were similar in both groups. The Apnea-Hypopnea Index (IHA) similar in both groups (30.4 +/- 20.9 RVO vs. 33.7 +/- 22.1 controls). In addition, RVO patients had a less favorable lipid profile, with higher total cholesterol (218 +/- 52 mg/dL vs. 179 +/- 41 mg/dL), higher LDL cholesterol (139 +/- 47 mg/dL vs. 107 +/- 32 mg/dL) and higher atherogenic indices: LDL/HDL (2.78 +/- 0.95 RVO vs. 2.03 +/- 0.67 controls) and total cholesterol/HDL (4.37 +/- 1.08 vs. 3.45 +/- 0.84). Among the cases, 81% had peripheral RVO (superior temporal branch in 20 out of 21 cases) and 19% had central RVO. A percentage of 62% of the cases received intravitreal antiangiogenic therapy and dexamethasone implants and 33% received argon laser photocoagulation. CONCLUSIONS: Poor control of cardiovascular risk factors, particularly dyslipidemias, in patients with OSA may lead to the development of this ocular complication.