Relationships of Fat Mass Index and Fat-Free Mass Index with Low-Density Lipoprotein Cholesterol Levels in the Tohoku Medical Megabank Community-Based Cohort Study

被引:0
|
作者
Takase, Masato [1 ]
Nakamura, Tomohiro [2 ,3 ]
Nakaya, Naoki [1 ,2 ]
Kogure, Mana [1 ,2 ]
Hatanaka, Rieko [1 ,2 ]
Nakaya, Kumi [1 ,2 ]
Chiba, Ippei [1 ,2 ]
Kanno, Ikumi [1 ,2 ]
Nochioka, Kotaro [1 ,2 ,4 ]
Tsuchiya, Naho [1 ,2 ]
Hirata, Takumi [2 ,5 ]
Obara, Taku [1 ,2 ]
Ishikuro, Mami [1 ,2 ]
Uruno, Akira [2 ]
Kobayashi, Tomoko [1 ,2 ,4 ]
Kodama, Eiichi N. [2 ,6 ]
Hamanaka, Yohei [2 ]
Orui, Masatsugu [1 ,2 ]
Ogishima, Soichi [1 ,2 ]
Nagaie, Satoshi [1 ,2 ]
Fuse, Nobuo [1 ,2 ]
Sugawara, Junichi [1 ,2 ,4 ,7 ]
Izumi, Yoko [1 ,2 ]
Kuriyama, Shinichi [1 ,2 ,6 ]
Hozawa, Atsushi [1 ,2 ,8 ]
机构
[1] Tohoku Univ, Grad Sch Med, Sendai, Miyagi, Japan
[2] Tohoku Univ, Tohoku Med Megabank Org, Sendai, Miyagi, Japan
[3] Kyoto Womens Univ, Kyoto, Japan
[4] Tohoku Univ, Tohoku Univ Hosp, Sendai, Miyagi, Japan
[5] Nara Med Univ, Inst Clin & Translat Sci, Nara, Japan
[6] Tohoku Univ, Int Res Inst Disaster Sci, Sendai, Miyagi, Japan
[7] Suzuki Mem Hosp, Iwanuma, Miyagi, Japan
[8] Tohoku Univ, Tohoku Med Megabank Org, Aoba Ku, Sendai, Miyagi, Japan
关键词
Adipose tissue; Muscle mass; Body composition; Epidemiology; Low-density lipoprotein cholesterol; ADIPOSE-TISSUE; BODY-FAT; DYSLIPIDEMIA; OBESITY; INFLAMMATION; MECHANISMS; PREDICTOR; DIAGNOSIS; DISEASES;
D O I
10.5551/jat.64535
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Aims: Although fat mass (FM) and fat-free mass (FFM) have an impact on lipid metabolism, the relationship between different body composition phenotypes and lipid profiles is still unclear. By dividing the FM and FFM by the square of the height, respectively, the f at mass index (FMI) and fat-free mass index (FFMI) can be used to determine the variations in body composition. This study aimed to investigate the relationship of combined FMI and FFMI with low-density lipoprotein cholesterol (LDL-C) levels. Methods: This cross-sectional study comprised 5,116 men and 13,630 women without cardiovascular disease and without treatment for hypertension, and diabetes. Following sex-specific quartile classification, FMI and FFMI were combined into 16 groups. Elevated LDL-C levels were defined as LDL-C >= 140 mg/dL and/or dyslipidemia treatment. Mu ltivariable logistic regression models were used to examine the relationships between combined FMI and FFMI and elevated LDL-C levels. Results: Overall, elevated LDL-C levels were found in 1,538 (30.1%) men and 5,434 (39.9%) women. In all FFMI subgroups, a higher FMI was associated with elevated LDL-C levels. Conversely, FFMI was inversely associated with elevated LDL-C levels in most FMI subgroups. Furthermore, the groups with the highest FMI and lowest FFMI had higher odds ratios for elevated LDL-C levels than those with the lowest FMI and highest FFMI. Conclusions: Regardless of FFMI, FMI was positively associated with elevated LDL-C levels. Conversely, in the majority of FMI subgroups, FFMI was inversely associated with elevated LDL-C levels.
引用
收藏
页码:979 / 1003
页数:25
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