Harnessing synthetic biology for advancing RNA therapeutics and vaccine design

被引:9
作者
Pfeifer, Blaine A. [1 ]
Beitelshees, Marie [2 ]
Hill, Andrew [2 ]
Bassett, Justin [1 ]
Jones, Charles H. [2 ]
机构
[1] Univ Buffalo State Univ New York, Dept Chem & Biol Engn, Buffalo, NY USA
[2] Pfizer, 66 Hudson Blvd, New York, NY 10001 USA
关键词
DELIVERY-SYSTEMS; LISTERIOLYSIN-O; GENE-EXPRESSION; MESSENGER-RNA; MURINE MODEL; GUIDE RNA; PROTEIN; APTAMERS; ANTIGEN; CONSTRUCTION;
D O I
10.1038/s41540-023-00323-3
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Recent global events have drawn into focus the diversity of options for combatting disease across a spectrum of prophylactic and therapeutic approaches. The recent success of the mRNA-based COVID-19 vaccines has paved the way for RNA-based treatments to revolutionize the pharmaceutical industry. However, historical treatment options are continuously updated and reimagined in the context of novel technical developments, such as those facilitated through the application of synthetic biology. When it comes to the development of genetic forms of therapies and vaccines, synthetic biology offers diverse tools and approaches to influence the content, dosage, and breadth of treatment with the prospect of economic advantage provided in time and cost benefits. This can be achieved by utilizing the broad tools within this discipline to enhance the functionality and efficacy of pharmaceutical agent sequences. This review will describe how synthetic biology principles can augment RNA-based treatments through optimizing not only the vaccine antigen, therapeutic construct, therapeutic activity, and delivery vector. The enhancement of RNA vaccine technology through implementing synthetic biology has the potential to shape the next generation of vaccines and therapeutics.
引用
收藏
页数:10
相关论文
共 137 条
  • [1] Abu Lila AS, 2017, BIOL PHARM BULL, V40, P1, DOI 10.1248/bpb.b16-00624
  • [2] Aptamers: A Review of Their Chemical Properties and Modifications for Therapeutic Application
    Adachi, Tatsuo
    Nakamura, Yoshikazu
    [J]. MOLECULES, 2019, 24 (23):
  • [3] Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis
    Adams, D.
    Gonzalez-Duarte, A.
    O'Riordan, W. D.
    Yang, C. -C.
    Ueda, M.
    Kristen, A. V.
    Tournev, I.
    Schmidt, H. H.
    Coelho, T.
    Berk, J. L.
    Lin, K. -P.
    Vita, G.
    Attarian, S.
    Plante-Bordeneuve, V.
    Mezei, M. M.
    Campistol, J. M.
    Buades, J.
    Brannagan, T. H., III
    Kim, B. J.
    Oh, J.
    Parman, Y.
    Sekijima, Y.
    Hawkins, P. N.
    Solomon, S. D.
    Polydefkis, M.
    Dyck, P. J.
    Gandhi, P. J.
    Goyal, S.
    Chen, J.
    Strahs, A. L.
    Nochur, S. V.
    Sweetser, M. T.
    Garg, P. P.
    Vaishnaw, A. K.
    Gollob, J. A.
    Suhr, O. B.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2018, 379 (01) : 11 - 21
  • [4] Ultrasensitive aptamer-functionalized Cu-MOF fluorescent nanozyme as an optical biosensor for detection of C-reactive protein
    Ali, Gona K.
    Omer, Khalid M.
    [J]. ANALYTICAL BIOCHEMISTRY, 2022, 658
  • [5] Highly Sensitive RNA-Based Electrochemical Aptasensor for the Determination of C-Reactive Protein Using Carbon Nanofiber-Chitosan Modified Screen-Printed Electrode
    Amouzadeh Tabrizi, Mahmoud
    Acedo, Pablo
    [J]. NANOMATERIALS, 2022, 12 (03)
  • [6] Synthetic biology devices and circuits for RNA-based 'smart vaccines': a propositional review
    Andries, Oliwia
    Kitada, Tasuku
    Bodner, Katie
    Sanders, Niek N.
    Weiss, Ron
    [J]. EXPERT REVIEW OF VACCINES, 2015, 14 (02) : 313 - 331
  • [7] Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine
    Baden, Lindsey R.
    El Sahly, Hana M.
    Essink, Brandon
    Kotloff, Karen
    Frey, Sharon
    Novak, Rick
    Diemert, David
    Spector, Stephen A.
    Rouphael, Nadine
    Creech, C. Buddy
    McGettigan, John
    Khetan, Shishir
    Segall, Nathan
    Solis, Joel
    Brosz, Adam
    Fierro, Carlos
    Schwartz, Howard
    Neuzil, Kathleen
    Corey, Larry
    Gilbert, Peter
    Janes, Holly
    Follmann, Dean
    Marovich, Mary
    Mascola, John
    Polakowski, Laura
    Ledgerwood, Julie
    Graham, Barney S.
    Bennett, Hamilton
    Pajon, Rolando
    Knightly, Conor
    Leav, Brett
    Deng, Weiping
    Zhou, Honghong
    Han, Shu
    Ivarsson, Melanie
    Miller, Jacqueline
    Zaks, Tal
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (05) : 403 - 416
  • [8] Phase 3 Trial of RNAi Therapeutic Givosiran for Acute Intermittent Porphyria
    Balwani, Manisha
    Sardh, Eliane
    Ventura, Paolo
    Peiro, Paula Aguilera
    Rees, David C.
    Stoelzel, Ulrich
    Bissell, D. Montgomery
    Bonkovsky, Herbert L.
    Windyga, Jerzy
    Anderson, Karl E.
    Parker, Charles
    Silver, Samuel M.
    Keel, Sioban B.
    Wang, Jiaan-Der
    Stein, Penelope E.
    Harper, Pauline
    Vassiliou, Daphne
    Wang, Bruce
    Phillips, John
    Ivanova, Aneta
    Langendonk, Janneke G.
    Kauppinen, Raili
    Minder, Elisabeth
    Horie, Yutaka
    Penz, Craig
    Chen, Jihong
    Liu, Shangbin
    Ko, John J.
    Sweetser, Marianne T.
    Garg, Pushkal
    Vaishnaw, Akshay
    Kim, Jae B.
    Simon, Amy R.
    Gouya, Laurent
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2020, 382 (24) : 2289 - 2301
  • [9] Recombinant protein expression in Escherichia coli
    Baneyx, F
    [J]. CURRENT OPINION IN BIOTECHNOLOGY, 1999, 10 (05) : 411 - 421
  • [10] Inotersen Treatment for Patients with Hereditary Transthyretin Amyloidosis
    Benson, M. D.
    Waddington-Cruz, M.
    Berk, J. L.
    Polydefkis, M.
    Dyck, P. J.
    Wang, A. K.
    Plante-Bordeneuve, V.
    Barroso, F. A.
    Merlini, G.
    Obici, L.
    Scheinberg, M.
    Brannagan, T. H., III
    Litchy, W. J.
    Whelan, C.
    Drachman, B. M.
    Adams, D.
    Heitner, S. B.
    Conceicao, I.
    Schmidt, H. H.
    Vita, G.
    Campistol, J. M.
    Gamez, J.
    Gorevic, P. D.
    Gane, E.
    Shah, A. M.
    Solomon, S. D.
    Monia, B. P.
    Hughes, S. G.
    Kwoh, T. J.
    McEvoy, B. W.
    Jung, S. W.
    Baker, B. F.
    Ackermann, E. J.
    Gertz, M. A.
    Coelho, T.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2018, 379 (01) : 22 - 31