Ethnopharmacological analysis based on Thai traditional medicine theory and anti-inflammatory activity of Sa-Tri-Lhung-Klod remedy as a post-partum anti-inflammatory drug

被引：1

作者：

Inprasit, Janjira ^{[1
]}

Itharat, Arunporn ^{[2
,3
,7
,8
]}

Ruangnoo, Srisopa ^{[2
]}

Thisayakorn, Krittiya ^{[4
]}

Sukkasem, Kanmanee ^{[2
]}

Prommee, Nuntika ^{[2
]}

Khoenok, Wicheian ^{[4
]}

Sriyam, Kanjana ^{[4
]}

Pahusee, Darunee ^{[4
]}

Davies, Neal M. ^{[5
,6
]}

机构：

[1] Thammasat Univ, Fac Med, Grad Sch, Dept Appl Thai Tradit Med, Klongluang 12120, Pathumthani, Thailand

[2] Thammasat Univ, Fac Med, Dept Appl Thai Tradit Med, Klongluang 12120, Pathumthani, Thailand

[3] Thammasat Univ, Ctr Excellence Appl Thai Tradit Med Res CEATMR, Klongluang 12120, Pathumthani, Thailand

[4] Thailand Inst Sci & Technol Res TISTR, Expert Ctr Innovat Herbal Prod InnoHerb, Pathum Thani 12120, Thailand

[5] Thammasat Univ, Khlong Luang 12120, Pathum Thani, Thailand

[6] Univ Alberta, Fac Pharm & Pharmaceut Sci, Katz Ctr Pharm & Hlth Res, Edmonton, AB T6G 2E1, Canada

[7] Thammasat Univ, Fac Med, Dept Appl Thai Tradit Med, Pathum Thani 12120, Thailand

[8] Thammasat Univ, Fac Med, Ctr Excellence Appl Thai Tradit Med Res CEATMR, Pathum Thani 12120, Thailand

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2024年 / 319卷

关键词：

Sa-Tri-Lhung-Klod remedy; Thai traditional medicine; Anti-Inflammatory activity; HPLC fingerprints; CURCUMA-COMOSA; ARTOCARPUS-HETEROPHYLLUS; EXTRACT; INFLAMMATION; EXPRESSION; ROOT; RAT; PAW; IDENTIFICATION; ANTIBACTERIAL;

D O I：

10.1016/j.jep.2023.117207

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Ethnopharmacological relevance: Sa-Tri-Lhung-Klod (ST) remedy is a Thai traditional remedy used in obstetrics and gynecology to reduce inflammation and nourish the body post-partum. In Thai traditional medicine (TTM), there is a theory of formulating drugs based on the four elements and the tastes of herbs for use in treating diseases.Aims of study: To determine relationships between taste theory and pharmacological properties for the antiinflammatory effect of ST remedy and its chemical constituent components. To evaluate anti-inflammatory activity and also investigate the HPLC fingerprint of ST extracts.Materials and methods: ST remedy was extracted by maceration in 95% ethanol (STE) and decoction in distilled water (STW). ST extracts were evaluated for anti-inflammatory activity by nitric oxide inhibitory assay in RAW264.7 cells, carrageenan-induced rat paw edema, and prostaglandin E2 inhibitory assay in inflamed rat paw tissue. In addition, the chemical constituent fingerprints of ST extracts were examined using HPLC.Results: STE contained seven main chemical compounds, and STW demonstrated only one identifiable chemical compound. The STE and STW displayed potent NO inhibitory activity with an IC50 value of 20.59 +/- 0.03 and 52.93 +/- 0.90 mu g/mL, respectively. Moreover, the STE and STW (at doses of 100 -400 mg/kg) promoted significant inhibition of inflammation in carrageenan-induced paw edema in rats (20.81 -38.25%). Additionally, the STE (200 -400 mg/kg) and STW (100 -400 mg/kg) significantly reduced PGE2 levels in inflamed rat paw tissue.Conclusion: These findings suggest that the spicy, astringent, sweet, and fragrant taste of the ST remedy used to treat post-partum inflammation encompass constituents with potent anti-inflammatory activity. STE and STW possess anti-inflammatory properties and effectively inhibit the production of NO and PGE2. Results confirm the use of the ST remedy for treating inflammatory diseases in the post-partum period according to TTM knowledge.

引用

页数：12