No Association of Angiotensin-Converting Enzyme Insertion/Deletion (ACE I/D) Gene Polymorphism in the Susceptibility to Diabetic Retinopathy in Type 2 Diabetes Mellitus Patients: An Updated Meta-Analysis

被引:2
作者
Coelho, Aline Ruilowa de Pinho [1 ]
Silveira, Luciana Carvalho [1 ]
Santos, Kamilla de Faria [1 ]
Santos, Rodrigo da Silva [1 ,2 ]
Reis, Angela Adamski da Silva [1 ,2 ]
机构
[1] Univ Fed Goias, Biol Sci Inst, Lab Mol Pathol, BR-74690090 Goiania, Brazil
[2] Univ Fed Goias, Biol Sci Inst, Dept Biochem & Mol Biol, BR-74690090 Goiania, Brazil
关键词
ACE gene; diabetic retinopathy; genetic polymorphism; type 2 diabetes mellitus; DELETION POLYMORPHISM; NEPHROPATHY; SYSTEM; COMPLICATIONS; RISK;
D O I
10.3390/jpm13091308
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Diabetic retinopathy (DR) is a complex and multifactorial pathology encompassing environmental, metabolic, and polygenic influences. Among the genes possibly involved in the development and progression of DR, the Angiotensin I-converting enzyme (ACE) gene stands out, which presents an insertion (I) or deletion (D) polymorphism of a 287 bp Alu repetitive sequence in intron 16. Thus, this study aimed to perform a systematic review with meta-analysis to elucidate the relationship between the ACE gene (I/D) polymorphism (rs1799752) and the development and progression of DR in type 2 diabetic patients. PubMed/MEDLINE, Embase, Web of Science, and Scopus databases were systematically searched to retrieve articles that investigated the association between ACE gene (I/D) polymorphism in DR patients. Sixteen articles were included in the systematic review. The results describe no significant association between the polymorphism and DR risk (OR = 1.12; CI = 0.96-1.31; and p = 0.1359) for genotypic analysis by the dominant model (II vs. ID+DD). Moreover, we also observed no significant association between the D allele on the allele frequency analysis (I vs. D) and the DR risk (OR = 1.10; CI = 0.98-1.23; and p = 0.1182). Forest plot analysis revealed that the discrepancy between previous studies most likely arose from variations in their sample sizes. In conclusion, I/D polymorphism appears to be not involved in the susceptibility to and progression of the DR in type 2 diabetic patients.
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页数:14
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